482R-1

p63 (EP174) Rabbit Monoclonal Primary Antibody

• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: EP174
• Application: IHC (p)
• Citations: 4

Eigenschaften

• biological source: rabbit
• Quality Level: 100, 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP174
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (482R-14), vial of 0.1 mL concentrate, Research Use Only (482R-14-RUO), vial of 0.5 mL concentrate (482R-15), vial of 1.0 mL concentrate (482R-16), vial of 1.0 mL concentrate, Research Use Only (482R-16-RUO), vial of 1.0 mL pre-dilute ready-to-use, Research Use Only (482R-17-RUO), vial of 1.0 mL pre-dilute, ready to use (482R-17), vial of 25.0 mL pre-dilute ready-to-use (482R-10), vial of 25.0 mL pre-dilute ready-to-use, Research Use Only (482R-10-RUO), vial of 7.0 mL pre-dilute, ready to use (482R-18), vial of 7.0 mL pre-dilute, ready to use, Research Use Only (482R-18-RUO)
• manufacturer/tradename: Cell Marque
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (1:100-1:200 (concentrated))
• isotype: IgG
• control: lung (squamous cell carcinoma), prostate
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear

Beschreibung

General description

p63 is a transcription factor that regulates many cell activities, including cell proliferation, maintenance, differentiation, adhesion, and apoptosis.¹ It has been found to be a sensitive and specific marker of myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland. Additionally, p63 has also demonstrated immunohistochemical utility in identifying benign and malignant breast lesions.² In prostatic carcinomas, it can also be used to recognize benign glands adjacent to malignant glands.³ p63 can also be used to differentiate adenocarcinoma of the lungs, where it is usually negative, from squamous cell carcinoma, which can be useful for advanced stages of the carcinoma where surgery is no longer an option.⁴

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

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Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 2