379R-1

Carbonic Anhydrase IX (CA IX) (EP161) Rabbit Monoclonal Primary Antibody

• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: EP161, monoclonal
• Application: IHC (p)
• Citations: -

Eigenschaften

• biological source: rabbit
• Quality Segment: 100, 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP161, monoclonal
• description: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• form: buffered aqueous solution
• species reactivity: human
• packaging: bottle of 1.0 mL predilute (379R-17), bottle of 7.0 mL predilute (379R-18), vial of 0.1 mL concentrate (379R-14), vial of 0.5 mL concentrate (379R-15), vial of 1.0 mL concentrate (379R-16)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
• isotype: IgG
• shipped in: wet ice
• storage temp.: 2-8°C
• Gene Information: human ... CA9(768)

Beschreibung

General description

Carbonic anhydrases are a family of zinc containing metalloproteins that catalyze the reversible hydration of CO₂. Among these, carbonic anhydrase IX (CA IX) is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach and gall bladder¹. It is interesting to note that CA IX is overexpressed in epithelial malignancies of the uterus, cervix, lung, breast, and kidney; none of the associated normal tissues express this isozyme.^1-4 CA IX is said to maintain the extracellular acidic pH, thus promoting cell growth in these tumors.⁵ Preliminary data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC) with demonstrated sensitivity of 85% to 100%.² Anti-CA IX, together with antibodies against PAX-2, Ksp-cadherin, and CD117, contributes to a robust panel that can be used to help make this distinction. Strong diffuse-to-multifocal immunostaining for anti-CA IX is observed in the large majority of urothelial carcinomas as opposed to the extremely weak and focal immunoreactivity seen in collecting duct carcinoma (CDC). Anti-CA IX can thus aid in distinguishing between urothelial carcinoma and CDC.⁶

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD

IVD

IVD

RUO

Other Notes

Carbonic Anhydrase IX (CA IX) Positive Control Slides, Product No. 379S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable