29311

CHES

BioUltra, ≥99.5% (T)

• Synonym(e): 2-(Cyclohexylamino)-ethansulfonsäure
• Empirische Formel (Hill-System): C₈H₁₇NO₃S
• CAS-Nummer: 103-47-9
• Molekulargewicht: 207.29
• UNSPSC Code: 12161700
• NACRES: NA.25
• PubChem Substance ID: 57648360
• EC Number: 203-115-6
• Beilstein/REAXYS Number: 2967601
• MDL number: MFCD00003835

Eigenschaften

• product line: BioUltra
• Quality Segment: 200
• assay: ≥99.5% (T)
• form: powder
• impurities: insoluble matter, passes filter test
• ign. residue: ≤0.05%
• loss: ≤0.5% loss on drying, 110 °C
• pH: 3.0-5.0 (25 °C, 0.5 M in H₂O)
• useful pH range: 8.6-10.0
• pKa (25 °C): 9.3
• solubility: H₂O: 0.5 M at 20 °C, clear, colorless
• anion traces: chloride (Cl^-): ≤50 mg/kg, sulfate (SO₄^2-): ≤500 mg/kg
• cation traces: Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg
• λ: 0.5 M in H₂O
• UV absorption: λ: 260 nm A_max: 0.08, λ: 280 nm A_max: 0.05
• SMILES string: OS(=O)(=O)CCNC1CCCCC1
• InChI: 1S/C8H17NO3S/c10-13(11,12)7-6-9-8-4-2-1-3-5-8/h8-9H,1-7H2,(H,10,11,12)
• InChI key: MKWKNSIESPFAQN-UHFFFAOYSA-N

Beschreibung

General description

Cyclohexylaminoethanesulfonic acid (CHES) is a buffering agent. Its structure contains a hydrophilic taurine (2-aminoethanesulfonic acid) moiety and a hydrophobic cyclohexyl group. CHES binds to the active site of several enzymes and inhibits substrate binding and enzymatic activity. Therefore, CHES may be used as a scaffold for new drug development for regulating enzyme activity.[1]

Application

2-(Cyclohexylamino)ethanesulfonic acid (CHES) has been used in the preparation of dimethyl trisulfide- polysorbate 80 (DMTS-PS80) formulation.[2]

Other Notes

Buffer for studying pH-dependent processes in enzymology; Has a high affinity for the iodoacetate binding site of liver alcohol dehydrogenase.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves