Fortfahren mit
262A-1
Granzyme B Rabbit Polyclonal Antibody
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Über diesen Artikel
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
Ig fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (262A-14), vial of 0.5 mL concentrate (262A-15), bottle of 1.0 mL predilute (262A-17), vial of 1.0 mL concentrate (262A-16), bottle of 7.0 mL predilute (262A-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
control
ALCL, spleen
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... GZMB(3002)
General description
Granzymes are serine proteases which are stored in specialized lytic granules of cytotoxic T-lymphocytes and in natural killer cells.[1] Anti-granzyme B has been useful in diagnosing natural killer/T-cell lymphoma, as well as anaplastic large cell lymphoma. High percentages of cytotoxic T-cells have been shown to be an unfavorable indicator in Hodgkin disease.[2][3][4][5]
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
Granzyme B Positive Control Slides, Product No. 262S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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J J Oudejans et al.
Blood, 89(4), 1376-1382 (1997-02-15)
Although the results of treatment of Hodgkin's disease (HD) have improved considerably in the last decades, the disease remains fatal in a minority of patients. We have recently shown that numbers of activated cytotoxic T cells (CTLs), present in tumor
Naoko Kato et al.
The American Journal of dermatopathology, 25(2), 142-147 (2003-03-26)
A neutrophil-rich anaplastic large cell lymphoma (ALCL) presented in the skin of a 47-year-old Japanese woman. The solitary cutaneous lesion was an eroded, 10-mm, dome-shaped nodule involving the skin of her left upper arm. Histologically, it showed a proliferation of
J J Oudejans et al.
The American journal of pathology, 148(1), 233-240 (1996-01-01)
Reed-Sternberg (RS) and Hodgkin's (H) cells are considered to be the neoplastic cells in Hodgkin's disease. Although most data suggest a lymphoid origin, the nature of these cells still remains the subject of considerable controversy. Recently, monoclonal antibodies became available
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 262A-14 | 0841683131397 |
| 262A-17 | 0841683131427 |
| 262A-18 | 0841683131434 |
| 262A-15 | 0841683131403 |
| 262A-16 | 0841683131410 |