T3383

Tetracyclin -hydrochlorid

≥95% (European Pharmacopoeia HPLC assay), meets EP testing specifications

• Synonym(e): 4-Epitetracycline hydrochloride, Achromycin hydrochloride
• Empirische Formel (Hill-System): C₂₂H₂₄N₂O₈ · HCl
• CAS-Nummer: 64-75-5
• Molekulargewicht: 480.90
• UNSPSC Code: 51284043
• NACRES: NA.76
• PubChem Substance ID: 24900135
• EC Number: 200-593-8
• Beilstein/REAXYS Number: 3844873
• MDL number: MFCD00078142

Eigenschaften

• agency: meets EP testing specifications
• Quality Segment: 200
• assay: ≥95% (European Pharmacopoeia HPLC assay)
• form: powder
• storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
• color: yellow
• mp: 220-223 °C (lit.)
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: protein synthesis | interferes
• storage temp.: −20°C
• SMILES string: Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
• InChI key: XMEVHPAGJVLHIG-FMZCEJRJSA-N

Beschreibung

General description

Chemical structure: tetracycline

Application

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L.

Biochem/physiol Actions

Wirkungsweise: Inhibiert die Proteinsynthese (Elongation) durch Verhinderung des Bindens von Aminoacyl-tRNA an die 30S-Untereinheit.

Antimikrobielles Spektrum: Gram-negative und Gram-positive Bakterien.

Resistenzmechanismus: Verlust der Zellwandpermeabilität.

Preparation Note

The product is freely soluble in water, soluble in methanol and ethanol but is insoluble in ether and hydrocarbons. In water, the product yields a clear, yellow-orange solution with heating and in 95% ethanol, 50 mg dissolved in 4 mL with heating yields a clear, yellow-green solution. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Disclaimer

This product should be frozen below 0°C and protected from light and moisture. In these conditions, the product has been shown to retain activity for 4 years. Stock solutions should be stored at -20°C and are stable at 37°C for 4 days.

Sicherheitshinweise

• pictograms: GHS08,GHS07,GHS09
• signalword: Warning
• hcodes: H315,H319,H335,H361fd,H410
• pcodes: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves