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P9375

Sigma-Aldrich

1,10-Phenanthrolin Monohydrat

reagent grade

Synonym(e):

o-Phenanthrolin Monohydrat

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About This Item

Empirische Formel (Hill-System):
C12H8N2 · H2O
CAS-Nummer:
5144-89-8
Molekulargewicht:
198.22
Beilstein:
4008096
EG-Nummer:
200-629-2
MDL-Nummer:
MFCD00149973
UNSPSC-Code:
12352116
PubChem Substanz-ID:
24278663
NACRES:
NA.77
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Qualität

reagent grade

Form

powder

mp (Schmelzpunkt)

100-104 °C (lit.)

Löslichkeit

methanol: 200 mM (Stock solution is stable for months at –20° C.)

SMILES String

O.c1cnc2c(c1)ccc3cccnc23

InChI

1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2

InChIKey

PPQJCISYYXZCAE-UHFFFAOYSA-N

Angaben zum Gen

human ... FNTA(2339)

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Allgemeine Beschreibung

Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. These complexes have wide applications in biochemistry, catalysis and analytical chemistry.[1] It complexes with iron and is exploited as a redox indicator.[2]

Anwendung

Im Komplex mit Kupfer besitzt es Nuklease-Aktivität, was zur Untersuchung von DNA-Protein-Interaktionen ausgenutzt wird.
1,10-Phenanthroline monohydrate has been used:
  • as an inhibitor of metalloproteinase (MMP) in MDA-MB-231 breast cancer cells[3]
  • as a negative control in in situ zymography of mice heart samples[4]
  • in in vitro resveratrol chelation and reducing activities assays to chelate iron[5]

Biochem./physiol. Wirkung

Inhibitor von Metalloproteasen; bildet Chelate mit Eisen, Zink und anderen zweiwertigen Metallen. Wirksam im Konzentrationsbereich von 1-10 mM.

Piktogramme

Skull and crossbonesEnvironment
GHS06,GHS09

Signalwort

Danger

H-Sätze

H301,H410

Gefahreneinstufungen

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000434933
0000434933
0000424774
0000424774
0000377981

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

The transmodulation of HER2 and EGFR by substance P in breast cancer cells requires c-Src and metalloproteinase activation
Garcia-Recio S, et al.
PLoS ONE, 10(6), e0129661-e0129661 (2015)
Electrochemical and DFT study of the reduction of substituted phenanthrolines
Ferreira H, et al.
Polyhedron, 122, 147-154 (2017)
Central Role of Phenanthroline Mono-N-oxide in the Decomposition Reactions of Tris (1, 10-phenanthroline) iron (II) and-iron (III) Complexes
Beller G, et al.
Inorganic Chemistry, 49(9), 3968-3970 (2010)
Resveratrol attenuates iron-induced toxicity in a chronic post-treatment paradigm in Caenorhabditis elegans
Soares MV, et al.
Free Radical Research, 52(9), 939-951 (2018)
Katy Satué et al.
Acta veterinaria Hungarica, 68(1), 79-84 (2020-05-10)
In women and females of different species of laboratory animals, oestrogens stimulate the renin-angiotensin-aldosterone system (RAAS) by increasing tissue and circulating levels of angiotensinogen and renin during the preovulatory period. Progesterone and cortisol compete with aldosterone for mineralocorticoid receptors, which
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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