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Merck

F8880

Supelco

Fluocinolon-acetonid

analytical standard

Synonym(e):

6α,9α-Difluor-11β,16α,17α,21-tetrahydroxy-1,4-pregnadien-3,20-dion, 6α,9α-Difluor-16α-hydroxyprednisolon-16,17-acetonid, 6α-Fluortriamcinolon Acetonid, Synandon

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About This Item

Empirische Formel (Hill-System):
C24H30F2O6
CAS-Nummer:
Molekulargewicht:
452.49
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

Assay

≥97.5% (HPLC)

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

267-269 °C (lit.)

Anwendung(en)

forensics and toxicology
veterinary

Format

neat

SMILES String

CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO

InChI

1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1

InChIKey

FEBLZLNTKCEFIT-VSXGLTOVSA-N

Angaben zum Gen

human ... NR3C1(2908)

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Anwendung

Fluocinolone acetonide may be used as a reference standard in the analysis of fluocinolone acetonide in samples of soil via pressurized liquid extraction (PLE) and solid-phase extraction (SPE) followed by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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Analysenzertifikate (COA)

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John H Kempen et al.
Ophthalmology, 120(9), 1852-1859 (2013-05-28)
To evaluate agreement between fluorescein angiography (FA) and optical coherence tomography (OCT) results for diagnosis of macular edema in patients with uveitis. Multicenter cross-sectional study. Four hundred seventy-nine eyes with uveitis from 255 patients. The macular status of dilated eyes
Soraya Rofagha et al.
Ocular immunology and inflammation, 21(1), 77-78 (2013-01-18)
To describe a case of spontaneous dissociation of a fluocinolone acetonide implant (Retisert) 5 years following implantation. Case report. A patient with chronic uveitis underwent placement of a fluocinolone acetonide implant in the right eye in 2006. The patient's inflammation
Analytical method for the determination of trace levels of steroid hormones and corticosteroids in soil, based on PLE/SPE/LC-MS/MS.
Gineys N, et al.
Analytical and Bioanalytical Chemistry, 397(6), 2295-2302 (2010)
Bryn M Burkholder et al.
Retina (Philadelphia, Pa.), 33(8), 1684-1693 (2013-04-04)
To evaluate outcomes after placement of fluocinolone acetonide (FA) implants in eyes with birdshot chorioretinitis and to compare these outcomes with eyes with posterior and panuveitis. This is a retrospective cohort study of 48 eyes from patients with posterior and
Peter A Campochiaro et al.
Ophthalmology, 119(10), 2125-2132 (2012-06-26)
To assess long-term efficacy and safety of intravitreal inserts releasing 0.2 μg/d (low dose) or 0.5 μg/d (high dose) fluocinolone acetonide (FAc) in patients with diabetic macular edema (DME). Two randomized, sham injection-controlled, double-masked, multicenter clinical trials. Subjects with persistent

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