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Dokumente

A3035

Sigma-Aldrich

4-Acetamidophenol

analytical standard

Synonym(e):

4′-Hydroxyacetanilid, N-(4-Hydroxyphenyl)acetamid, N-Acetyl-4-aminophenol, APAP, Acetaminophen, Paracetamol

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About This Item

Lineare Formel:
CH3CONHC6H4OH
CAS-Nummer:
103-90-2
Molekulargewicht:
151.16
Beilstein:
2208089
EG-Nummer:
203-157-5
MDL-Nummer:
MFCD00002328
UNSPSC-Code:
41116107
PubChem Substanz-ID:
24890717
NACRES:
NA.21

Qualität

analytical standard

Qualitätsniveau

300

Form

powder

Verpackung

vial of 1 g

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

168-172 °C (lit.)

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

SMILES String

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChIKey

RZVAJINKPMORJF-UHFFFAOYSA-N

Angaben zum Gen

human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

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Verwandte Kategorien

Anwendung

Analgetikum

Verpackung

Geliefert In Braunglas-Vials

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

364.3 °F - Pensky-Martens closed cup

Flammpunkt (°C)

184.6 °C - Pensky-Martens closed cup

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
0000373100
0000366464
0000373099
0000321410
0000373100

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Sigma-Aldrich

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Sigma-Aldrich

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Acetylsalicylsäure

4-Aminophenol ≥98%

Sigma-Aldrich

A71328

4-Aminophenol

Aspirin United States Pharmacopeia (USP) Reference Standard

USP

1044006

Aspirin

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Sigma-Aldrich

77440

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Magnesiumsalicylat United States Pharmacopeia (USP) Reference Standard

USP

1374306

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Acetaminophen solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

A-064

Acetaminophen solution

Ibuprofen

Supelco

I110

Ibuprofen

Karel Allegaert et al.
Archives of disease in childhood, 98(6), 462-466 (2013-04-23)
There remains a need for alternative medical treatments for patent ductus arteriosus (PDA) closure in extreme preterm neonates because of therapeutic failure and adverse effects associated with non-selective cyclo-oxygenase inhibitors. Reports of an association between paracetamol exposure and PDA closure
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Edward Munsterhjelm et al.
Anesthesiology, 103(4), 712-717 (2005-09-30)
Acetaminophen (paracetamol) is widely used for postoperative analgesia. Its mechanism of action is inhibition of prostaglandin synthesis in the central nervous system, and acetaminophen is traditionally not considered to influence platelet function. The authors studied the dose-dependent inhibition of platelet
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective
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