93938

Aloe-Emodin

analytical standard

• Synonym(e): 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinon, 1,8-Dihydroxy-3-hydroxymethylanthraquinon, 3-Hydroxymethylchrysazin, Rhabarberon
• Empirische Formel (Hill-System): C₁₅H₁₀O₅
• CAS-Nummer: 481-72-1
• Molekulargewicht: 270.24
• UNSPSC Code: 85151701
• NACRES: NA.24
• PubChem Substance ID: 329770287
• EC Number: 207-571-7
• Beilstein/REAXYS Number: 2059062
• MDL number: MFCD00017373

Eigenschaften

• grade: analytical standard
• Quality Segment: 100
• assay: ≥97.0% (HPLC)
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• color: light orange to dark orange
• application(s): food and beverages
• format: neat
• storage temp.: 2-8°C
• SMILES string: OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
• InChI: 1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
• InChI key: YDQWDHRMZQUTBA-UHFFFAOYSA-N

Beschreibung

General description

Aloe-emodin is a hydroxyanthraquinone and an active component present in Aloe vera leaves and root/rhizome of Rheum palmatum, possessing specific in vitro and in vivo antineuroectodermal tumor activity.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Aloe-emodin may be used as a reference standard in the determination of aloe-emodin in Aloe vera extracts and commercial formulations using high-performance liquid chromatography (HPLC) coupled with tandem UV absorption and fluorimetric detection.

Biochem/physiol Actions

Abführmittel; erhöht die Kontraktion der glatten Darmmuskulatur durch Freisetzung endogenen Acetylcholins. Eine Anti-Tumor-Wirkung steht im Zusammenhang mit einer erhöhten Produktion von reaktiven Sauerstoff-Spezies (ROS), die wiederum das elektrische Potential der mitochondrialen Transmembran reduzieren und somit einen Permeabilitätsübergang induzieren, der eine Reihe von Vorgängen in Bewegung setzt, deren kulminierende Wirkung der Zelltod ist. Gentoxizität und Mutagenität scheinen auf der Hemmung der Topoisomerase II Aktivität durch Aloe-Emodin zu beruhen

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This compound is commonly found in plants of the genus: aloe

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable