83580

Reserpin

≥99.0% (HPLC), serotonin uptake inhibitor, solid

• Synonym(e): (3β, 16β, 17α, 18β, 20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carbonsäure-methylester
• Empirische Formel (Hill-System): C₃₃H₄₀N₂O₉
• CAS-Nummer: 50-55-5
• Molekulargewicht: 608.68
• NACRES: NA.77
• PubChem Substance ID: 329769078
• UNSPSC Code: 12352200
• EC Number: 200-047-9
• MDL number: MFCD00005091
• Beilstein/REAXYS Number: 102014
• Assay: ≥99.0% (HPLC)
• Form: solid

Eigenschaften

• Produktname: Reserpin, crystallized, ≥99.0% (HPLC)
• assay: ≥99.0% (HPLC)
• form: solid
• optical activity: [α]20/D −123±3°, c = 1% in chloroform
• quality: crystallized
• mp: ~265 °C (dec.)
• SMILES string: CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6
• InChI: 1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
• InChI key: QEVHRUUCFGRFIF-MDEJGZGSSA-N
• Gene Information: human ... SLC18A2(6571)

Beschreibung

General description

Reserpine is an indole alkaloid that irreversibly binds vesicular monoamine transporters VMAT1 and VMAT2. It is a sympatholytic drug useful in treating systemic hypertension.

Application

Reserpine has been used as a test chemical in performance studies.

Biochem/physiol Actions

Reserpine is used to treat hypertensive pregnancy difficulties. This drug is also considered as antipsychotic and antihypertensive, to regulate high blood pressure.

Hemmt die vesikuläre Aufnahme von Catecholaminen und Serotonin.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H336,H351,H360D
• pcodes: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3
• target_organs: Central nervous system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves