83580

Reserpin

crystallized, ≥99.0% (HPLC)

• Synonym(e): (3β, 16β, 17α, 18β, 20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carbonsäure-methylester
• Empirische Formel (Hill-System): C₃₃H₄₀N₂O₉
• CAS-Nummer: 50-55-5
• Molekulargewicht: 608.68
• Beilstein: 102014
• EG-Nummer: 200-047-9
• MDL-Nummer: MFCD00005091
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329769078
• NACRES: NA.77

Eigenschaften

• Assay: ≥99.0% (HPLC)
• Form: solid
• Optische Aktivität: [α]20/D −123±3°, c = 1% in chloroform
• Qualität: crystallized
• mp (Schmelzpunkt): ~265 °C (dec.)
• SMILES String: CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6
• InChI: 1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
• InChIKey: QEVHRUUCFGRFIF-MDEJGZGSSA-N
• Angaben zum Gen: human ... SLC18A2(6571)

Beschreibung

Allgemeine Beschreibung

Reserpine is an indole alkaloid that irreversibly binds vesicular monoamine transporters VMAT1 and VMAT2. It is a sympatholytic drug useful in treating systemic hypertension.

Anwendung

Reserpine has been used as a test chemical in performance studies.

Biochem./physiol. Wirkung

Reserpine is used to treat hypertensive pregnancy difficulties. This drug is also considered as antipsychotic and antihypertensive, to regulate high blood pressure.

Hemmt die vesikuläre Aufnahme von Catecholaminen und Serotonin.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H336,H351,H360D
• P-Sätze: P201 - P301 + P312 + P330 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves