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81091

Sigma-Aldrich

Dextromethorphan -hydrobromid Monohydrat

tested according to Ph. Eur.

Synonym(e):

Dextromethorphan hydrobromicum, (9S,13S,14S)-3-Methoxy-17-methylmorphinan -hydrobromid

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About This Item

Empirische Formel (Hill-System):
C18H25NO · HBr · H2O
CAS-Nummer:
6700-34-1
Molekulargewicht:
370.32
Beilstein:
6453793
MDL-Nummer:
MFCD02173901
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329769208

Agentur

USP/NF
tested according to Ph. Eur.

Form

solid

Anwendung(en)

pharmaceutical (small molecule)

SMILES String

Br[H].[H]O[H].[H][C@]12CCCC[C@]13CCN(C)[C@H]2Cc4ccc(OC)cc34

InChI

1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1

InChIKey

STTADZBLEUMJRG-IKNOHUQMSA-N

Angaben zum Gen

human ... GRIN2A(2903) , SIGMAR1(10280)

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Anwendung

Produkt-Nr.
Beschreibung
Preisangaben

Piktogramme

Skull and crossbonesEnvironment
GHS06,GHS09

Signalwort

Danger

H-Sätze

H301,H411

Gefahreneinstufungen

Acute Tox. 3 Oral - Aquatic Chronic 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Analysenzertifikate (COA)

Lot/Batch Number
BCBR1973V
BCBN4182V
BCBL6486V
BCBD0663
1432935

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F L Opdam et al.
Cancer chemotherapy and pharmacology, 71(3), 593-601 (2012-12-12)
Adjuvant therapy with tamoxifen significantly reduces breast cancer recurrence and mortality in estrogen receptor positive disease. CYP2D6 is the main enzyme involved in the activation of the prodrug tamoxifen into the anti-estrogen endoxifen. Endoxifen is thought to be a main
Melanie A Paquette et al.
The European journal of neuroscience, 36(9), 3224-3234 (2012-08-07)
Amantadine and dextromethorphan suppress levodopa (L-DOPA)-induced dyskinesia (LID) in patients with Parkinson's disease (PD) and abnormal involuntary movements (AIMs) in the unilateral 6-hydroxydopamine (6-OHDA) rat model. These effects have been attributed to N-methyl-d-aspartate (NMDA) antagonism. However, amantadine and dextromethorphan are
Tao-Cheng Wu et al.
PloS one, 7(9), e46067-e46067 (2012-10-11)
Vascular oxidative stress may be increased with age and aggravate endothelial dysfunction and vascular injury in hypertension. This study aimed to investigate the effects of dextromethorphan (DM), a NADPH oxidase inhibitor, either alone or in combination treatment, on blood pressure
Fixed drug eruption due to dextromethorphan with tolerance to other opioids.
G Davila-Fernández et al.
Journal of investigational allergology & clinical immunology, 23(4), 281-282 (2013-08-24)
K N Chi et al.
Cancer chemotherapy and pharmacology, 71(1), 237-244 (2012-10-16)
To assess the effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan HBr (CYP2D6 substrate) and theophylline (CYP1A2 substrate) in patients with metastatic castration-resistant prostate cancer (mCRPC). Men with progressive metastatic mCRPC who failed gonadotropin-releasing hormone therapy and
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