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Merck

38907

Supelco

Isorhamnetin

analytical standard

Synonym(e):

3′-Methoxy-3,4′,5,7-tetrahydroxy-flavon, 3′-Methylquercetin, 3,4′,5,7-Tetrahydroxy-3′-methoxyflavon, Isorhamnetol, Quercetin-3′-methylether

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About This Item

Empirische Formel (Hill-System):
C16H12O7
CAS-Nummer:
Molekulargewicht:
316.26
Beilstein:
44723
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
85151701
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

Assay

≥99% (HPLC)

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

food and beverages

Format

neat

Lagertemp.

2-8°C

SMILES String

COc1cc(ccc1O)C2=C(O)C(=O)c3c(O)cc(O)cc3O2

InChI

1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3

InChIKey

IZQSVPBOUDKVDZ-UHFFFAOYSA-N

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Allgemeine Beschreibung

Isorhamnetin belongs to the flavonoids class of compounds.

Anwendung

Isorhamnetin may be used as an analytical reference standard for the determination of isorhamnetin in:
  • Rat plasma samples by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) equipped with electrospray ionization (ESI) and multiple reaction monitoring (MRM) mode of detection.
  • Lotus (Nelumbo nucifera) leaves by macroporous resin chromatography combined with HPLC-ESI-MS/MS.
  • Powdered extracts and finished products samples of Ginkgo biloba by HPLC-MS.
  • Human plasma and urine by high-throughput micro solid-phase extraction (μ-SPE), followed by analysis using UHPLC in interface with quadrupole time-of-flight mass spectrometry (Q TOFMS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

Isorhamnetin inhibits adipogenesis by interfering with differentiation of adipose stem cells, by a mechanism involving stabilization of β-catenin and up-regulating the Wnt signaling pathway.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sonstige Hinweise

This compound is commonly found in plants of the genus: ginkgo glycyrrhiza primula

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Analysis of flavonoids in lotus (Nelumbo nucifera) leaves and their antioxidant activity using macroporous resin chromatography coupled with LC-MS/MS and antioxidant biochemical assays.
Zhu MZ, et al.
Molecules (Basel), 20(6), 10553-10565 (2015)
An effective identification and quantification method for Ginkgo biloba flavonol glycosides with targeted evaluation of adulterated products.
Ma YC, et al.
Phytomedicine, 23(4), 377-387 (2016)
Chemical fingerprint and quantitative analysis of flavonoids for quality control of Sea buckthorn leaves by HPLC and UHPLC-ESI-QTOF-MS.
Dong R, et al.
Journal of functional foods, 37, 513-522 (2017)
Development and validation of a high-throughput micro solid-phase extraction method coupled with ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry for rapid identification and quantification of phenolic metabolites in human plasma and urine.
Feliciano RP, et al.
Journal of Chromatography A, 1464(4), 21-31 (2016)
Simultaneous Determination of Kaempferide, Kaempferol and Isorhamnetin in Rat Plasma by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study.
Jiang Z, et al.
Journal of the Brazilian Chemical Society, 29(3), 535-542 (2018)

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