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17849

Enrofloxacin

≥99.0%

Synonym(e):

Baytril

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PackungsgrößeSKUVerfügbarkeitPreis
5 g
Warenkorb auf Verfügbarkeit prüfen
€ 141,00
25 g
Warenkorb auf Verfügbarkeit prüfen
€ 559,00
€ 391,30

Über diesen Artikel

Empirische Formel (Hill-System):
C19H22FN3O3
CAS-Nummer:
Molekulargewicht:
359.39
UNSPSC Code:
41116105
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5307824

€ 141,00


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Quality Segment

assay

≥99.0%, 99.0-101.0% (dried substance)

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

SMILES string

CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4

InChI

1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)

InChI key

SPFYMRJSYKOXGV-UHFFFAOYSA-N

General description

Chemical structure: fluoroquinolone
Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.[1][2][3]

Application

Enrofloxacin has been used:
  • to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells[1]
  • to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)[2]
  • as an analyte in a chemiluminescence reagent system[4]

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Dieser Artikel
33699PHR15131235900
mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

-

mode of action

-

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

-

assay

≥99.0%, 99.0-101.0% (dried substance)

assay

-

assay

-

assay

-

form

powder or crystals

form

-

form

-

form

-

Quality Level

200

Quality Level

100

Quality Level

300

Quality Level

-


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pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)



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Global Trade Item Number

SKUGTIN
17849-25G-F04061838753793
17849-5G-F04061838753809

Questions

1–2 of 2 Questions  
  1. Is it possible to store the drug frozen for long-term preservation after dissolving it in organic solvents?

    1 answer
    1. The solution stability has not been tested. However, literature research suggests that enrofloxacin solutions dissolved in organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO) stored under frozen conditions can typically remain stable for approximately 26 to 52 weeks (6 to 12 months). The exact stability can depend on factors such as concentration, formulation, and specific storage conditions.

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  2. What is the solubility of Antibiotic Question 17849 in water? This is intended for use in a mouse experiment involving drinking water.

    1 answer
    1. The substance is not soluble in water. It has a solubility of 1mg/ml in organic solvents such as DMSO and 10 mg/ml in DMF. Additionally, it is suggested to try if the drug dissolves in (2-Hydroxypropyl)-β-cyclodextrin solution H5784.

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