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MAB5216

Anti-NMDAR2A Antibody

Name: Anti-NMDAR2A Antibody
Brand: MM
Price: 506 EUR

Chemicon^®, from mouse

Synonym(e):

NR2A

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Packungsgröße	SKU	Verfügbarkeit	Preis
100 μg		Warenkorb auf Verfügbarkeit prüfen	€ 506,00

Über diesen Artikel

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

monoclonal

Application:

ICC, IHC (p), WB

Citations:

€ 506,00

Warenkorb auf Verfügbarkeit prüfen

Für Ihr Target ist ein rekombinanter, konservierungsmittelfreier Antikörper verfügbar. Probieren Sie ZRB04901

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Eigenschaften

biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

clone

monoclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

technique(s)

immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000833.2

UniProt accession no.

Q12879

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GRIN2A(2903)

Beschreibung

Immunogen

Amino acid region 1099-1213 from human NMDAR2A produced as a GST fusion protein.

Application

Anti-NMDAR2A Antibody detects level of NMDAR2A & has been published & validated for use in IH(P), IC, IH & WB.

Immunohistochemistry (light and EM) on 4% paraformaldehyde & 0.125% glutaraldehyde fixed tissue: 2.5-5 μg/mL.

Immunocytochemistry: 2.5-5.0μg/mL

Western blot: 1-5 μg/mL Optimal working dilutions must be determined by end user.

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

Physical form

Affinity purified immunoglobulin. Liquid in PBS. Contains no preservative.

Format: Purified

Preparation Note

Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: MAB5218

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Dieser Artikel	MAB5572	AB1548	SAB5200904
Sigma-Aldrich MAB5216 Anti-NMDAR2A Antibody	Sigma-Aldrich MAB5572 Anti-NMDAR2A Antibody	Sigma-Aldrich AB1548 Anti-NMDAR2A&B Antibody, pan	Sigma-Aldrich SAB5200904 Monoclonal Anti-Glun2A/Nr2A - Rpe antibody produced in mouse
clone monoclonal	clone 2H9.24A6, monoclonal	clone polyclonal	clone S327-95, monoclonal
antibody form affinity purified immunoglobulin	antibody form ascites fluid	antibody form affinity isolated antibody	antibody form purified immunoglobulin
species reactivity human	species reactivity frog, rat, human, rabbit, mouse	species reactivity mouse, guinea pig, rat, human, rabbit, avian	species reactivity human, mouse, rat
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate phycoerythrin (R-PE) conjugate
Gene Information human ... GRIN2A(2903)	Gene Information human ... GRIN2A(2903)	Gene Information human ... GRIN2A(2903)	Gene Information rat ... Grin2a(24409)
biological source mouse	biological source mouse	biological source rabbit	biological source mouse

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Lagerklasse

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Verwandter Inhalt

Pathways and Biomarkers of Glutamatergic Synapse Flyer

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

Anti-NMDAR2A - Data Sheet

MOUSE ANTI-NMDAR2A

Global Trade Item Number

SKU	GTIN
MAB5216	04053252662195

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