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Über diesen Artikel
conjugate
unconjugated
Quality Segment
antibody form
affinity purified immunoglobulin
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, rabbit, human
concentration
(Please refer to lot specific datasheet.)
technique(s)
immunohistochemistry: suitable, western blot: suitable
UniProt accession no.
target post-translational modification
unmodified
General description
Application
Biochem/physiol Actions
Physical form
Preparation Note
Analysis Note
Western Blotting Analysis: 2.0 µg/mL of this antibody detected EMX1 in 10 µg of human fetal brain tissue lysate.
Other Notes
Disclaimer
Lagerklasse
10 - Combustible liquids
Analysenzertifikate (COA)
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Verwandter Inhalt
Alzheimer’s Disease is a progressively deteriorating disease. It manifests itself with memory loss, confusion, problems with judgment, planning, concentration, and personality changes; and in it’s later stages, a decline in physical abilities. The disease’s causes, cures, and preventions are unknown; however, key proteins likely involved in the degenerative mechanism have been identified. Alzheimer’s Disease is characterized by neuronal loss, alterations in neurotransmitter systems, and the presence of neurofibrillary tangles composed of abnormally hyperphosphorylated tau proteins. A prominent feature of Alzheimer’s Disease is the formation of senile plaques in selected regions of the brain. The center of these plaques are composed mainly of fibrillary aggregates of a common, but not well understood, b amyloid peptides (Aβ). The Aβ peptides are generated from the larger amyloid-β precursor protein (APP) by the sequential action of β- and γ-secretase, and it is generally accepted that oligomeric forms of this Aβ are neurotoxic, resulting in disease progression.