8.52117

Fmoc-Glu-O-2-PhiPr

Novabiochem^®

• Synonym(e): Fmoc-Glu-O-2-PhiPr, N-α-Fmoc-L-glutamic acid α-2-phenylisopropyl ester
• Empirische Formel (Hill-System): C₂₉H₂₉NO₆
• CAS-Nummer: 207305-97-3
• Molekulargewicht: 487.54
• MDL number: MFCD10001339
• UNSPSC Code: 12352209
• NACRES: NA.22

Eigenschaften

• Quality Level: 200
• product line: Novabiochem^®
• assay: ≥92.0% (acidimetric), ≥95% (TLC), ≥95.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: carboxylic acid
• storage temp.: 15-25°C
• SMILES string: N([C@@H](CCC(=O)O)C(=O)OC(C)(C)c4ccccc4)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C29H29NO6/c1-29(2,19-10-4-3-5-11-19)36-27(33)25(16-17-26(31)32)30-28(34)35-18-24-22-14-8-6-12-20(22)21-13-7-9-15-23(21)24/h3-15,24-25H,16-18H2,1-2H3,(H,30,34)(H,31,32)/t25-/m0/s1
• InChI key: UFFILNXPAXHSBT-VWLOTQADSA-N

Beschreibung

General description

An excellent tool for the synthesis of head-to-tail cyclic peptides by Fmoc SPPS ^[1]. The 2-PhiPr group can be selectively removed on the resin with 1% TFA in DCM in the presence of the standard t-butyl-based side-chain protecting groups.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS

Literature references

^[1] F. Dick, et al. in ′Peptides 1996, Proc. of 24th European Peptide Symposium′, R. Ramage & R. Epton (Eds), Mayflower Scientific Ltd., Birmingham, 1998, pp. 339.

Analysis Note

Colour (visual): white to yellow
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (DC(018A)): ≥ 95 %
Purity (TLC(0811)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): passes test
Assay (acidimetric): ≥ 92.0 %
Water (K. F.): ≤ 2.5 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-12-1284

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable