8.43943

Propanephosphonic acid anhydride

(50% solution in 2-Methyltetrahydrofuran) for synthesis T3P

• Synonym(e): 2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution, PPACA, Propylphosphonic anhydride, T3P
• NACRES: NA.22
• UNSPSC Code: 12352108
• Form: liquid

Eigenschaften

• Quality Segment: 200
• form: liquid
• bp: 78-80 °C/1013 hPa (solvent)
• transition temp: flash point -11 °C (solvent)
• density: 1.039 g/cm³ at 20 °C
• storage temp.: 2-8°C

Beschreibung

Application

• Study on the propylphosphonic anhydride (T3P) mediated Ugi-type three-component reaction. Efficient synthesis of an α-amino amide library: Explores the use of T3P in a three-component Ugi reaction, demonstrating its utility in synthesizing a diverse library of α-amino amides (Milen et al., 2017).


• Cyclization of Linear Tetrapeptides Containing N‐Methylated Amino Acids by using 1‐Propanephosphonic Acid Anhydride: Reports the unexpected findings during the cyclization of linear tetrapeptides, where T3P played a crucial role in enhancing the reaction outcomes (Zhang et al., 2017).

Analysis Note

Assay (T3P) (NMR): ≥ 40.0 %
Pyropropanephosphonic acid (NMR): ≤ 10.0 %
Propanephosphonic acid (NMR): ≤ 0.50 %
2- Methyltetrahydrofurane (calculated): ≤ 50.0 %