692000

ZM 336372

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC₅₀ = 70 nM).

• Synonym(e): ZM 336372, N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
• Empirische Formel (Hill-System): C₂₃H₂₃N₃O₃
• CAS-Nummer: 208260-29-1
• Molekulargewicht: 389.45
• MDL-Nummer: MFCD02683971
• UNSPSC-Code: 12352117
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: off-white
• Löslichkeit: DMSO: 200 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
• InChIKey: PYEFPDQFAZNXLI-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of c-Raf (IC₅₀ = 70 nM). Inhibits c-Raf with ten-fold greater potency compared to B-Raf. Has no significant effect on many other protein kinases tested (even at 50 µM) with the exception of SAPK2a/p38α (IC₅₀ = 2 µM) and SAPK2b/p38β2 (IC₅₀ = 2 µM).

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC₅₀ = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC₅₀ = 2 µM) and SAPK2b/p38β2 (IC₅₀ = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
Protein kinase c-Raf

Product competes with ATP.

Reversible: yes

Target IC₅₀: 70 nM against protein kinase c-Raf

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

Sonstige Hinweise

Hall-Jackson, C.A., et al. 1999. Chem. Biol.6, 559.

Rechtliche Hinweise

Sold under license of PCT Application W098/22,103.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H317,H413
• P-Sätze: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Gefahreneinstufungen: Aquatic Chronic 4 - Skin Sens. 1B
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable