658460

AG 879 - CAS 148741-30-4 - Calbiochem

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation.

• Synonym(e): AG 879 - CAS 148741-30-4 - Calbiochem, α-Cyano-(3,5-di- t-butyl-4-hydroxy)thiocinnamide
• Empirische Formel (Hill-System): C₁₈H₂₄N₂OS
• CAS-Nummer: 148741-30-4
• Molekulargewicht: 316.46
• MDL-Nummer: MFCD00236450
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: orange-yellow
• Löslichkeit: DMSO: 100 mg/mL; acetic acid: soluble; methanol: soluble
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+
• InChIKey: LCUMYVYIHXYBIA-FOWTUZBSSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation. Also blocks NGF-induced neurite outgrowth in PC12 cells. Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Inhibits insulin secretion in a dose-dependent manner.

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent pp140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM), as well as NGF-induced phospholipase C-γ1 phosphorylation. Also shown to inhibit HER2 (IC₅₀ = 1 µM). Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Also inhibits insulin secretion in a dose-dependent manner.

Biochem./physiol. Wirkung

Cell permeable: yes

EC50 = 10 µM inhibiting nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation

Primary Target
(NGF)-dependent p140c-trk tyrosine phosphorylation

Product does not compete with ATP.

Reversible: yes

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.







From Catalog:

Solubility- removed acetic acid, MeOH

Sonstige Hinweise

Konrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
Ohmichi, M., et al. 1993. Biochemistry32, 4650.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 10-13 - German Storage Class 10 to 13