5.34347

hCNT2 Inhibitor

• Synonym(e): hCNT2 Inhibitor, 8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor
• Empirische Formel (Hill-System): C₂₃H₂₄N₆O₄
• CAS-Nummer: 880155-70-4
• Molekulargewicht: 448.47
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Eigenschaften

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: pale yellow
• solubility: DMSO: 50 mg/mL
• storage temp.: 2-8°C

Beschreibung

General description

An aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na⁺-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC₅₀ of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Primary Target
hCNT2

Reversible: yes

Target IC₅₀: 640 nM in COS-7 cells

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tatani, K., et al. 2015. ACS Med. Chem. Lett.6, 244.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable