528822

PARP Inhibitor XII

The PARP Inhibitor XII, also referenced under CAS 489457-67-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(e): PARP Inhibitor XII, 3-(4-Chlorophenyl)quinoxaline-5-carboxamide
• Empirische Formel (Hill-System): C₁₅H₁₀ClN₃O
• CAS-Nummer: 489457-67-2
• Molekulargewicht: 283.71
• MDL number: MFCD11856053
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: light brown
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Clc1ccc(cc1)c2nc3c(nc2)cccc3C(=O)N
• InChI: 1S/C15H10ClN3O/c16-10-6-4-9(5-7-10)13-8-18-12-3-1-2-11(15(17)20)14(12)19-13/h1-8H,(H2,17,20)
• InChI key: FLYGLPYJEQPCFY-UHFFFAOYSA-N

Beschreibung

General description

A potent quinoxaline-based PARP inhibitor with a ~5-fold selectivity towards PARP-2 over PARP-1 (IC₅₀ = 7 and 33 nM, respectively). Reported to be brain-permeant and exhibit good pharmacokinetics.

Packaging

Packaged under inert gas

Other Notes

Ishida, J., et al. 2006. Bioorg. Med. Chem.14, 1378.
Iwashita, A., et al. 2005. FEBS Lett.579, 1389.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable