481981

Nifedipine

≥98% (UV), L-type Ca2+ channel bocker, solid

• Synonym(e): Nifedipine, L-Type Calcium Channel Blocker III
• Empirische Formel (Hill-System): C₁₇H₁₈N₂O₆
• CAS-Nummer: 21829-25-4
• Molekulargewicht: 346.33
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00057326
• Assay: ≥98% (UV)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Produktname: Nifedipine, Relatively selective blocker of L-type Ca²⁺ channels.
• description: Merck USA index - 14, 6528
• Quality Segment: 100
• assay: ≥98% (UV)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow
• solubility: DMSO: soluble, ethanol: soluble
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [N+](=O)([O-])c1c(cccc1)C2C(=C(NC(=C2C(=O)OC)C)C)C(=O)OC
• InChI: 1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
• InChI key: HYIMSNHJOBLJNT-UHFFFAOYSA-N

Beschreibung

General description

Relatively selective blocker of L-type Ca²⁺ channels. One of the most extensively studied blockers of 1,4-dihydropyridine-type Ca²⁺ channels, and a pharmacologically-useful vasodilator. Induces apoptosis in human glioblastoma cells.

Biochem/physiol Actions

Product does not compete with ATP.

Reversible: no

Cell permeable: no

Primary Target
L-type Ca2+ channels

Preparation Note

Following reconstitution, refrigerate (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Reid, K., et al. 1997. J. Pharmacol. Exp. Ther. 283, 993.
Kondo, S., et al. 1995. J. Neurosurg.82, 469.
Antkiewicz-Michaluk, L., et al. 1994. Eur. J. Pharmacol. 254, 9.
Calabresi, P., et al. 1994. J. Neurosci. 14, 4871.
Akman, M.S., et al. 1993. Endocrinology132, 1286.
Cirillo, M., et al. 1993. Circ. Res.72, 847.
Young, R.J., et al. 1993. Biochim. Biophys. Acta1146, 81.
Janis, R., et al. 1987. Adv. Drug Res.16, 311.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable