475874-M

MK571, Sodium Salt

≥90% (HPLC), leukotriene D4receptor antagonist, solid

• Synonym(e): MK571, Sodium Salt, L 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt
• Empirische Formel (Hill-System): C₂₆H₂₆ClN₂O₃S₂ · Na
• CAS-Nummer: 115104-28-4
• Molekulargewicht: 537.07
• MDL number: MFCD00797675
• UNSPSC Code: 12352211
• NACRES: NA.77
• Assay: ≥90% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated

Eigenschaften

• Produktname: MK571, Sodium Salt, A selective, competitive antagonist of leukotriene D4 (LTD4) (K_i = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes).
• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: off-white
• solubility: DMSO: 10 mg/mL, water: 200 mg/mL
• storage temp.: −20°C
• SMILES string: S(C(SCCC(=O)O)c1cc(ccc1)\C=C\c2nc3c(cc2)ccc(c3)Cl)CCC(=O)N(C)C
• InChI: 1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+
• InChI key: AXUZQJFHDNNPFG-UXBLZVDNSA-N

Beschreibung

General description

A selective, competitive antagonist of leukotriene D₄ (LTD₄) receptor (K_i = 2.1 nM for inhibition of [³H]LTD₄ binding to human lung membranes). Also reported to inhibit multidrug resistance-associated protein 1 (MRP1).

Biochem/physiol Actions

Primary Target
Antagonist of leukotriene D4 (LTD4)

Target K_i: 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.

Other Notes

Olson, D.P., et al. 2001. Cytometry46, 105.
Van der Kolk, D.M., et al. 1998. Clin. Cancer Res.4, 1727.
Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol.67, 17.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable