14-856
Ubiquitin C-terminal hydrolase L3 (UCH-L3), 50 µg
From human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters & thioesters of the C-terminus of ubiquitin.
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 50 μg | Warenkorb auf Verfügbarkeit prüfen | € 427,00 |
Über diesen Artikel
UNSPSC Code:
12352200
NACRES:
NA.32
eCl@ss:
32160405
Specific activity:
>1000 pmol/min-μg, 25 °C (with 1 μM ubiquitin-AMC as substrate and UCH-L3 at 20 pM (0.58 ng/mL).)
Biological source:
human
Recombinant:
expressed in E. coli
Technischer Dienst
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Unterstützung erhaltenbiological source
human
Quality Level
recombinant
expressed in E. coli
specific activity
>1000 pmol/min-μg, 25 °C (with 1 μM ubiquitin-AMC as substrate and UCH-L3 at 20 pM (0.58 ng/mL).)
mol wt
Mw 26.2 kDa
manufacturer/tradename
Upstate®
NCBI accession no.
UniProt accession no.
shipped in
dry ice
General description
Produced from human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters and thioesters of the C-terminus of ubiquitin. UCH-L3 is a member of the lower molecular weight group of UCHs involved in the hydrolysis of small C-terminal derivatives of ubiquitin that form non-specifically during the process of protein ubiquitinylation.
Product Source: Recombinant human UCH-L3 expressed in E.coli.
Application
From human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters & thioesters of the C-terminus of ubiquitin.
Preparation Note
Store at -70°C for up to 12 months from date of receipt. As supplied, the enzyme is stable on ice for several hours. Activity is stable up to 6 freeze/thaw cycles (snap freezing in a dry/ice ethanol bath or liquid nitrogen).
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Dieser Artikel | |||
|---|---|---|---|
| specific activity >1000 pmol/min-μg, 25 °C (with 1 μM ubiquitin-AMC as substrate and UCH-L3 at 20 pM (0.58 ng/mL).) | specific activity >1000 pmol/min-μg, 25 °C (with 1 μM ubiquitin-AMC as substrate and UCH-L1 at 20 pM (0.54 ng/mL).) | specific activity - | specific activity - |
| biological source human | biological source human | biological source human | biological source - |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. - |
| mol wt Mw 26.2 kDa | mol wt Mw 24.8 kDa | mol wt - | mol wt - |
| shipped in dry ice | shipped in dry ice | shipped in - | shipped in ambient |
Lagerklasse
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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K D Wilkinson et al.
Journal of molecular biology, 291(5), 1067-1077 (1999-10-16)
The ubiquitin fold is a versatile and widely used targeting signal that is added post-translationally to a variety of proteins. Covalent attachment of one or more ubiquitin domains results in localization of the target protein to the proteasome, the nucleus
Shahram Misaghi et al.
The Journal of biological chemistry, 280(2), 1512-1520 (2004-11-09)
Ubiquitin C-terminal hydrolases (UCHs) comprise a family of small ubiquitin-specific proteases of uncertain function. Although no cellular substrates have been identified for UCHs, their highly tissue-specific expression patterns and the association of UCH-L1 mutations with human disease strongly suggest a
Roles of ubiquitinylation in proteolysis and cellular regulation
Wilkinson, K D
Annual Review of Nutrition, 15, 161-189 (1995)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 14-856 | 04053252674273 |