14-595-M

PP1α Protein, 10 µg

Recombinant, full length, human PP1α, for use in Phosphatase Assays.

• Synonym(e): PPP1C, Phosphoprotein phosphatase 1, Phosphorylase phosphatase
• UNSPSC Code: 12352200
• NACRES: NA.32
• eCl@ss: 32160405
• Form: solution
• Biological source: human
• Recombinant: expressed in E. coli
• Mol wt: M_w 37.6 kDa

Eigenschaften

• biological source: human
• Quality Level: 100
• recombinant: expressed in E. coli
• form: solution
• shelf life: 6 mo.
• mol wt: M_w 37.6 kDa
• manufacturer/tradename: Upstate^®
• technique(s): activity assay: suitable (phosphatase)
• solubility: water: soluble
• NCBI accession no.: NM_001008709.1, NM_002708.3, NM_206873.1
• UniProt accession no.: P62136
• storage temp.: −20°C
• Gene Information: human ... PPP1CA(5499)

Beschreibung

General description

Research area: Neuroscience
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.

Application

Research Category
Inflammation & Immunology

Biochem/physiol Actions

Protein Target: PP1α Target Sub-Family: Ser/Thr phosphatase

Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.[1]

Packaging

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-595M when ordering the 250 µg size.

Physical form

Heparin agarose followed by Q agarose

Preparation Note

6 months at -20°C from date of shipment

Analysis Note

routinely evaluated by dephosphorylation of 100μM DiFMUP

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 1