14-595-M
PP1α Protein, 10 µg
Recombinant, full length, human PP1α, for use in Phosphatase Assays.
Synonym(e):
PPP1C, Phosphoprotein phosphatase 1, Phosphorylase phosphatase
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About This Item
UNSPSC-Code:
12352200
eCl@ss:
32160405
NACRES:
NA.32
Empfohlene Produkte
Biologische Quelle
human
Qualitätsniveau
Rekombinant
expressed in E. coli
Form
solution
Haltbarkeit
6 mo.
Mol-Gew.
Mw 37.6 kDa
Hersteller/Markenname
Upstate®
Methode(n)
activity assay: suitable (phosphatase)
Löslichkeit
water: soluble
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
human ... PPP1CA(5499)
Allgemeine Beschreibung
Research area: Neuroscience
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.
Anwendung
Research Category
Entzündung & Immunologie
Entzündung & Immunologie
Biochem./physiol. Wirkung
Protein Target: PP1α Target Sub-Family: Ser/Thr phosphatase
Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.
Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.
Verpackung
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-595M when ordering the 250 µg size.
Qualität
routinely evaluated by dephosphorylation of 100μM DiFMUP
Physikalische Form
Heparin agarose followed by Q agarose
Lagerung und Haltbarkeit
6 months at -20°C from date of shipment
Sonstige Hinweise
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Skin Sens. 1
Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 1
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Alphonse Garcia et al.
Biochimie, 85(8), 721-726 (2003-10-31)
The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of
The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity.
Munton, Richard P, et al.
Febs Letters, 567, 121-128 (2004)
Modulation of dendritic spines by protein phosphatase-1
Advances in Pharmacology, 90.0, 117-144 (2021)
Karl Foley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(14), 3040-3050 (2021-04-09)
Protein phosphatases, by counteracting protein kinases, regulate the reversible phosphorylation of many substrates involved in synaptic plasticity, a cellular model for learning and memory. A prominent phosphatase regulating synaptic plasticity and neurologic disorders is the serine/threonine protein phosphatase 1 (PP1).
Targeting phosphatases as the next generation of disease modifying therapeutics for Parkinson?s disease
Braithwaite SP, et al.
Neurochemistry International, 61, 899-906 (2012)
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