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14-515

MAP Kinase 1/Erk1 Protein, inactive, 50 g

Unactive, N-terminal GST-tagged, recombinant, full-length, human MAP Kinase 1/Erk1, for use in Kinase Assays.

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Über diesen Artikel

UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405
Biological source:
human
Recombinant:
expressed in E. coli
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biological source

human

Quality Level

recombinant

expressed in E. coli

mol wt

Mw 70 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

UniProt accession no.

shipped in

dry ice

General description

N-terminal GST-tagged, recombinant, full-length, human MAP Kinase 1/Erk1
Product Source: expressed in E. coli

Application

Research Category
Metabolism
Research Sub Category
Obesity

Metabolic Disorders

Biochem/physiol Actions

Protein Target: MAPK1
Target Sub-Family: CMGC

Physical form

Glutathione-agarose

Preparation Note

6 months at -20°C

Analysis Note

routinely evaluated by phosphorylation of MBP substrate in vitro

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Dieser Artikel
14-53614-19814-439-M
biological source

human

biological source

human

biological source

mouse

biological source

human

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

-

UniProt accession no.

P28482

UniProt accession no.

P28482

UniProt accession no.

P63085

UniProt accession no.

P28482

mol wt

Mw 70 kDa

mol wt

Mw 67.8 kDa

mol wt

Mw 67.8 kDa

mol wt

Mw 69.9 kDa


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

Lagerklasse

10 - Combustible liquids

wgk

WGK 2



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Ivana Yen et al.
Cancer cell, 34(4), 611-625 (2018-10-10)
Targeting KRAS mutant tumors through inhibition of individual downstream pathways has had limited clinical success. Here we report that RAF inhibitors exhibit little efficacy in KRAS mutant tumors. In combination drug screens, MEK and PI3K inhibitors synergized with pan-RAF inhibitors



Global Trade Item Number

SKUGTIN
14-51504053252731983

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