1.08212

Parteck^® PLX 188 (Poloxamer 188)

(stabilized with 70ppm BHT), EMPROVE^® ESSENTIAL, Ph. Eur., NF

• Synonym(e): Poloxamer 188
• Lineare Formel: (C₃H₆O · C₂H₄O)_x
• CAS-Nummer: 9003-11-6
• MDL-Nummer: MFCD00082049
• UNSPSC-Code: 12352112

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 500
• Agentur: NF; Ph. Eur.
• Produktlinie: EMPROVE^® ESSENTIAL
• bp: >150 °C
• mp (Schmelzpunkt): 55 °C
• Schüttdichte: 1050 kg/m³
• Lagertemp.: 2-25°C
• SMILES String: O2C(C2)C.O1CC1
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• InChIKey: RVGRUAULSDPKGF-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid oral dosage forms. The products in our Parteck^® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Anwendung

Parteck^® PLX 188 excipient combines adequate lubrication at tolerable concentrations with the added benefit of dissolution enhancement. It features consistent performance, improved dissolution rate and reliable lubrication – all at the same time. As a result, Parteck^® PLX 188 excipient can therefore provide a simple solution to low bioavailability of DCS 2a compounds.

Leistungsmerkmale und Vorteile

• Hydrophilic, water-soluble tablet lubrication
• Improved dissolution rates for poorly soluble DCS class IIa molecules
• Specified particle size distribution optimized for solid application performance
• Regulatory support through compliance with Ph. Eur. and USP-NF, going beyond current requirements with specitied formaldehyde content

Rechtliche Hinweise

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable