439509

3-Acetyl-2,5-dichlorthiophen

98%

• Synonym(e): 2,5-Dichlor-3-thienyl-methyl-keton
• Empirische Formel (Hill-System): C₆H₄Cl₂OS
• CAS-Nummer: 36157-40-1
• Molekulargewicht: 195.07
• NACRES: NA.22
• PubChem Substance ID: 24867514
• UNSPSC Code: 12352100
• EC Number: 252-893-3
• MDL number: MFCD00014522
• Assay: 98%

Eigenschaften

• assay: 98%
• mp: 37-40 °C (lit.)
• SMILES string: CC(=O)c1cc(Cl)sc1Cl
• InChI: 1S/C6H4Cl2OS/c1-3(9)4-2-5(7)10-6(4)8/h2H,1H3
• InChI key: GYFDNIRENHZKGR-UHFFFAOYSA-N

Beschreibung

Application

3-Acetyl-2,5-dichlorothiophene may be used in the following syntheses:

• substituted chalcones[1]
• AL-4623A and AL-4862 (brinzolamide), inhibitors of topical carbonic anhydrase
• 2,5-dichlorothiophene-3-carboxylic acid, which is the starting reagent required for the synthesis of 2,5-dichloro-N-(substituted amino-carbonothioyl)thiophene-3-carboxamides and 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4-ones

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319,H335
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: 235.4 °F - closed cup
• flash_point_c: 113 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves