P9156
Plasminogen from bovine plasma
lyophilized powder, ≥2.0 units/mg protein
Sinónimos:
Profibrinolysin
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Número CAS:
UNSPSC Code:
12352202
eCl@ss:
42030240
EC Number:
232-641-9
NACRES:
NA.61
MDL number:
Specific activity:
≥2.0 units/mg protein
Biological source:
bovine plasma
Concentration:
2-7% protein (biuret)
biological source
bovine plasma
form
lyophilized powder
specific activity
≥2.0 units/mg protein
concentration
2-7% protein (biuret)
suitability
not suitable for streptokinase determination by clot formation procedure
application(s)
histology
storage temp.
2-8°C
Gene Information
cow ... PLG(280897)
human ... PLG(5340)
Biochem/physiol Actions
Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).
The activated form of plasminogen, plasmin, was shown to promote the migration of melanoma and lung tumor cells plated on the extracellular matrix protein laminin by altering protein kinase C signaling. [1]
Physical form
Lyophilized powder containing NaCl, EDTA, lysine, and Tris buffer salts
Preparation Note
Solutions should be stored in buffer containing 20 mM lysine at neutral pH. The protein should be as concentrated as possible. Frozen in aliquots at −20 °C, it should be stable for several weeks.
Other Notes
ε-Aminocaproic acid free
One unit will produce 1.0 μmole of p-nitroanilide from D-Val-Leu-Lys 4-nitroanilide at pH 7.5 at 37°C.
1 of 1
Este artículo | |||
|---|---|---|---|
| specific activity ≥2.0 units/mg protein | specific activity ≥2.0 units/mg protein | specific activity ≥120 units/mg protein | specific activity - |
| Gene Information cow ... PLG(280897) | Gene Information human ... PLG(5340) | Gene Information - | Gene Information cow ... FGA(522039), FGB(510522), FGG(280792) |
| biological source bovine plasma | biological source - | biological source human plasma | biological source bovine plasma |
| concentration 2-7% protein (biuret) | concentration - | concentration - | concentration 65-85% (biuret) |
| form lyophilized powder | form lyophilized powder | form lyophilized | form powder |
| application(s) histology | application(s) diagnostic assay manufacturing | application(s) - | application(s) - |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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L Chikahisa et al.
Invasion & metastasis, 17(6), 323-333 (1997-01-01)
Using a pure chemotactic model, we investigated the effect of plasmin on tumor cell motility. In the presence of various extracellular matrix proteins, plasmin facilitated motility of human melanoma LOX and lung cancer Lu-99 cells. Laminin contributed most to the
Yueling Zhang et al.
FEBS letters, 587(9), 1304-1309 (2013-03-12)
Cluster 1 streptokinases (SK1) from Streptococcus pyogenes (GAS) show substantially higher human plasminogen (hPg) activation activities and tighter hPg binding affinities than cluster 2b streptokinases (SK2b) in solution. The extent to which the different domains of SK are responsible for
Barbara Ruszkowska et al.
Acta obstetricia et gynecologica Scandinavica, 92(7), 841-846 (2013-03-12)
To assess the concentration of adiponectin, soluble E-selectin, soluble thrombomodulin and tissue activator plasminogen antigen in postmenopausal women who received oral or transdermal hormone therapy. Case-control study. Polish university hospitals. Seventy-six healthy postmenopausal women. Forty-six women who received oral (n
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| P9156-10UN | 04061833493168 |
| P9156-5UN | 04061834402503 |
| P9156-100UN | 04061833631508 |
| P9156-25UN | 04061833493175 |