Intensified and Continuous Upstream (USP) Processing
Prepare sus estrategias de fabricación para el futuro, reduzca los costes y aumente la flexibilidad de sus instalaciones con procesos de cultivo semicontinuo y perfusión intensificados
Make the best decisions to increase productivity, reduce costs, improve facility flexibility, and future-proof manufacturing strategies by intensifying your upstream process.
Biopharmaceutical developers and manufacturers need efficient, productive upstream processes that deliver high-quality monoclonal antibodies (mAbs) and other types of recombinant proteins. Process intensification, including intensified fed-batch and perfusion processes, offers many options to future-proof their manufacturing strategies, reduce costs, and increase facility flexibility.
With a full suite of solutions designed to support the increased demands of intensified upstream processes and technical support from teams with years of experience, we can support you in choosing the best strategies to realize the benefits of upstream process intensification without compromising clinical milestones or speed to market.
Intensified and Continuous Upstream (USP) Processing
Intensified and Continuous Upstream (USP) Processing
Today’s biopharmaceutical manufacturers are confronted with numerous challenges:
- Speed-to-market and cost-efficient production for competitive advantage
- Flexibility to increase throughput or target a smaller patient population
- Agility to process multiple products in a single facility
- High volumetric productivity with a smaller facility footprint
Upstream process intensification, as a cornerstone of this transformation, can deliver new gains in efficiency while sustaining or improving product quality. Whether you’re developing an intensified fed-batch or perfusion process, our integrated solutions enable you to increase volumetric productivity which can translate into higher throughput, improved facility utilization and flexibility, compressed timelines, and reduced manufacturing and capital costs.
Categorías relacionadas
Las operaciones de perfusión proporcionan cultivos celulares de gran densidad que alivian la carga de procesar grandes volúmenes en los biorreactores de producción...
Los productos y soluciones Mobius® pueden ayudarle a satisfacer sus requisitos de cultivo celular en constante evolución...
Con nuestra completa cartera de productos, puede elegir entre formulaciones probadas y verdaderas...
A cell line that maintains favorable growth and productivity is vital for mab manufacturing.
Recursos relacionados
- Mobius® iFlex Bioreactors for Fed-Batch and Perfusion Upstream Processes
The Mobius® iFlex Bioreactor takes modular flexibility, scalability, ergonomics...
- Mobius® Breez Microbioreactor for Perfusion Process Development
The pressure to reduce manufacturing costs is driving the need to improve process efficiency and flexibility...
- Cell Retention Technology and Specialized Cell Culture Media for Intensified Upstream Processing
This study demonstrates the use of a Cellicon® filter and controller in an N-1 perfusion process with Cellvento® 4CHO-X expansion medium as compared to a control seed train using shake flasks.
- Reproducible Scaling of a Cell Retention Filter Using the Cellicon® Cell Retention Solution
This page describes the design attributes of the Cellicon® Filter Assembly and how they simplify process scale-up.
- Operational and Financial Advantages of Cellicon® Cell Retention Solution in an N-1 Perfusion Process
The following study compares an N-1 perfusion process at the 2,000 L scale using our Cellicon® Cell Retention Solution versus a commercially available cell retention device.
- Seed Train Intensification Using High Cell Density Cryopreservation
This article explains the benefits of high cell density cryopreservation (HCDC) and how to implement it.
- Impact of DMSO And Freezing Technique in Developing a High Cell Density Cryopreservation Process for Upstream Bioprocessing
Here, we evaluated how dimethyl sulfoxide and freezing techniques impact viable cell density and titer production in an HCDC intensified seed train.
- Preparing CHO Cells for Higher Productivity by Optimizing a Perfused Seed Train
This application note describes the benefits and performance of Cellvento® 4CHO-X Expansion Medium designed for multiple cell expansion steps from vial thaw to N-1 stages to generate higher biomass for inoculating fed-batch production bioreactors.
- Flyer: Mobius® Breez Microbioreactor
A 2 mL Automated Perfusion Cell Culture Platform: Do more with less and accelerate your path to process intensification.
Seminarios virtuales relacionados
This webinar describes a new microbioreactor system that fulfills throughput-performance gap, providing single-use, perfusion bioreactors with 2mL working volume that can replicate bench scale perfusion processes at industrially relevant cell densities.
Explore el uso y los beneficios de la crioconservación de gran densidad celular (HCDC)
Se están desarrollando bioprocesos intensificados en las etapas iniciales para aumentar la productividad mientras que...
Learn how perfused seed train options could deliver lower cost of goods, increase product throughput, or a combination of both.
The integration of a perfused N-1 step in upstream process is highlighted to either decrease facility footprint or to be able to inoculate final fed-batch N-stage with a higher cell density as a conventional fed-batch.
Media composition plays a critical role for biopharmaceutical production as well as seed train expansion.
Upstream process intensification can bring significant benefits to manufacturers in terms of smaller facilities, manufacturing flexibility, and reduction in footprint, with achieving significantly higher productivity.
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