N7505

ββ-Nicotinamida adenina dinucleótico 2′-fosfato reducido tetrasodium salt hydrate

≥97% (HPLC)

• Sinónimos: ββ-NADPH, 2′-NADPH hydrate, Coenzima II reducida tetrasodium salt, Dihidronicotinamida adenina dinucleótido fosfato tetrasodium salt, NADPH Na₄, Nucleótido de trifosfopiridina reducido tetrasodium salt, TPNH₂ Na₄
• Fórmula empírica (notación de Hill): C₂₁H₂₆N₇Na₄O₁₇P₃ · xH₂O
• Número de CAS: 2646-71-1
• Peso molecular: 833.35 (anhydrous basis)
• EC Number: 220-163-3
• MDL number: MFCD00036263
• UNSPSC Code: 41106305
• PubChem Substance ID: 24278049
• NACRES: NA.51

Propiedades

• assay: ≥97% (HPLC); ≥97% (spectrophotometric assay)
• form: powder
• solubility: 10 mM NaOH: soluble 50 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [Na+].[Na+].[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](OP([O-])([O-])=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O
• InChI: 1S/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11+,13-,14+,15-,16+,20-,21+;;;;/m0..../s1
• InChI key: WYWWVJHQDVCHKF-MPUNMZHWSA-J

Descripción

Biochem/physiol Actions

El NADPH es un donante de electrones y un cofactor de muchas enzimas rédox, entre ellas la óxido nítrico sintetasa.

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects against reactive oxidation species accumulation. NADPH is generated in vivo by the pentose phosphate pathway (PPP).

Preparation Note

Chemically reduced

Other Notes

Envasado en función del peso sólido.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)