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F9765

Filipin complex

Name: Filipin complex
Brand: SIGMA
Price: 173000 CLP

powder, ≥70% (UV)

Sinónimos:

Filimarisin

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Tamaño de envase	SKU	Disponibilidad	Precio
25 mg		Comprobar disponibilidad del carrito	$173.000
50 mg		Comprobar disponibilidad del carrito	$418.000

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Número CAS:

11078-21-0

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00131073

$173.000

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Propiedades

Nombre del producto

Filipin complex from Streptomyces filipinensis, ≥70% (UV)

biological source

Streptomyces sp. (Streptomyces filipinensis)

Quality Segment

200

assay

≥70% (UV)

form

powder

solubility

methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow

antibiotic activity spectrum

fungi

mode of action

cell membrane | interferes

storage temp.

−20°C

InChI

1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1

InChI key

IMQSIXYSKPIGPD-YQRUMEKGSA-N

Descripción

General description

Chemical structure: macrolide

Application

Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.

Biochem/physiol Actions

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability and associated functions via binding to membrane sterols. Filipin binds to membrane sterols such as cholesterol, and it both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Other Notes

Filipin contains 8 isomeric components, with filipin III as the major component.

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Mostrar Diferencias

1 of 1

Este artículo	F4767	46745	O4876
Sigma-Aldrich F9765 Filipin complex from Streptomyces filipinensis	Sigma-Aldrich F4767 Filipin III from Streptomyces filipinensis	Supelco 46745 Spiramycin from Streptomyces sp.	Sigma-Aldrich O4876 Oligomycin from Streptomyces diastatochromogenes
biological source Streptomyces sp. (Streptomyces filipinensis)	biological source -	biological source -	biological source -
assay ≥70% (UV)	assay ≥85% (HPLC)	assay -	assay ≥90% total oligomycins basis (HPLC)
Quality Level 200	Quality Level 300	Quality Level 200	Quality Level 200
form powder	form powder	form -	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow	solubility methanol: 9.80-10.20 mg/mL, clear, colorless to yellow	solubility -	solubility -

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Número de artículo de comercio global

SKU	GTIN
F9765-25MG	04061833621981
F9765-50MG	04061833621998

Questions

1–6 of 6 Questions

3 years ago

What is the stability of filipin when dissolved in DMSO and stored at -20 degrees C (how long can it be stored like this)?

1 answer
1. Technical Support
  
  10 months ago
  
  This product has not been tested for stability in solution, however product SAE0088 is a prepared 5/mg/mL solution in DMSO. This product is stable for at least 2 years at -20 deg. C. but does contain a proprietary stabilizer to enhance stability. See the link below to the product information sheet on the SAE0088 solution:
  https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/973/858/sae0088pis.pdf
  Please navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a Certificate of Analysis for the prepared solution which includes the retest date:
  https://www.sigmaaldrich.com/product/sigma/f9765#product-documentation
  
  Helpful?
3 years ago

Which filipin is better to visualize cholesterol in hela cells by immunofluorescence - F9765 or F4767?

1 answer
1. Technical Support
  
  3 years ago
  
  Both F9765 and F4767 are suitable for determining cholesterol in cells. The F4767, Filipin III, is purified from Filipin. As it has a higher purity, it may offer a higher signal-to-noise ratio resulting in less background. These product have not been compared in side by side testing. It may be helpful to view the peer-reviewed knowledge articles to help with the appropriate selection:
  https://www.sigmaaldrich.com/search/f9765?focus=papers&page=1&perpage=30&sort=relevance&term=f9765&type=citation_search
  
  Helpful?
Anonymous

4 years ago

What is the Department of Transportation shipping information for this product?

1 answer
1. Technical Support
  
  4 years ago
  
  Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
  
  Helpful?
Anonymous

4 years ago

What is the difference between Filipin products F9765 and F4767?

1 answer
1. Technical Support
  
  4 years ago
  
  The product F9765 consists of a filipin complex. It is composed of 8 isomeric components, of which filipin III is the major component in the complex. F4767 consists of filipin III alone and is considered to be a better choice for staining.
  
  Helpful?
Anonymous

4 years ago

How should Product F9765, Filipin complex from Streptomyces filipinensis, be solubilized?

1 answer
1. Technical Support
  
  4 years ago
  
  This product has low solubility in aqueous buffers. It should initially be reconstituted in DMSO at 1 mg/mL and then diluted into saline or an aqueous buffer of choice.
  
  Helpful?
Anonymous

4 years ago

What is the stability of stock solutions Product F9765, Filipin complex from Streptomyces filipinensis?

1 answer
1. Technical Support
  
  4 years ago
  
  Solutions of filipin in aqueous or organic solvents are not considered to be stable and it is recommended that they be prepared fresh and not stored as stock solutions.
  
  Helpful?

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