F4767

Filipin III from Streptomyces filipinensis

≥85% (HPLC)

• Sinónimos: Filimarisin
• Fórmula empírica (notación de Hill): C₃₅H₅₈O₁₁
• Número CAS: 480-49-9
• Peso molecular: 654.83
• NACRES: NA.77
• PubChem Substance ID: 24894871
• UNSPSC Code: 12352202
• MDL number: MFCD00466923

Propiedades

• Quality Segment: 300
• assay: ≥85% (HPLC)
• form: powder
• mp: 163-180 °C
• solubility: methanol: 9.80-10.20 mg/mL, clear, colorless to yellow
• antibiotic activity spectrum: fungi, yeast
• mode of action: cell membrane | interferes
• storage temp.: −20°C
• SMILES string: CCCCCC(O)C1C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C(C)=C\C=C\C=C\C=C\C=C\C(O)C(C)OC1=O
• InChI: 1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14-
• InChI key: IMQSIXYSKPIGPD-BWJOQPJXSA-N

Descripción

Application

Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel and immobilized on nitrocellulose membranes.

Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel and immobilized on nitrocellulose membranes. It is also widely used to localize and quantitate unesterified cholesterol by virtue of a specific fluorescent complex.

Biochem/physiol Actions

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action may be due to altering membrane permeability and associated functions by binding to membrane sterols. Filipin inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Other Notes

Filipin III is the major component of 8 isomeric components in filipin.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves