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P4670

Propafenon -hydrochlorid

Synonym(e):

1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride

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Über diesen Artikel

Empirische Formel (Hill-System):
C21H27NO3 · HCl
CAS-Nummer:
34183-22-7
Molekulargewicht:
377.90
NACRES:
NA.77
PubChem Substance ID:
24278636
UNSPSC Code:
41116107
EC Number:
251-867-9
MDL number:
MFCD00079243
Form:
powder
Quality level:
100

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Unterstützung erhalten

form

powder

Quality Level

100

originator

Abbott

storage temp.

2-8°C

SMILES string

Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2

InChI

1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H

InChI key

XWIHRGFIPXWGEF-UHFFFAOYSA-N

Gene Information

human ... ABCB1(5243), ADRB1(153), ADRB2(154), ADRB3(155), CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Dieser Artikel
Y0000455SML06021570304
Propafenone hydrochloride

Sigma-Aldrich

P4670

Propafenone hydrochloride

Propafenone hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0000455

Propafenone hydrochloride

Propiverine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0602

Propiverine hydrochloride

Propafenone hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1570304

Propafenone hydrochloride

form

powder

form

-

form

powder

form

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

originator

Abbott

originator

-

originator

-

originator

-

Gene Information

human ... ABCB1(5243), ADRB1(153), ADRB2(154), ADRB3(155), CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Gene Information

human ... ADRB1(153), ADRB2(154), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Gene Information

-

Gene Information

human ... ADRB1(153), ADRB2(154), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

General description

Propafenone hydrochloride is a calcium antagonist. It functions as a Na+ and K+ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.

Application

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.

Biochem/physiol Actions

Blocks hKv1.5 and ATP-sensitive K+ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKCS0910
MKCN8139
MKCJ9681
MKCD0594
MKBW3969V

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Die Dokumentenbibliothek aufrufen

Lambert K Sørensen
Journal of analytical toxicology, 36(2), 116-122 (2012-02-18)
A liquid chromatography-tandem mass spectrometry method, using pneumatically assisted electrospray ionization was developed for the determination of amiodarone, desethylamiodarone, propafenone, N-depropylpropafenone, 5-OH-propafenone, flecainide, and sotalol in human antemortem and postmortem whole blood. A mixture of methanol and acetonitrile was used
David Lowes et al.
Journal of medicinal chemistry, 55(13), 6087-6093 (2012-06-20)
Previously reported studies identified analogues of propafenone that had potent antimalarial activity, reduced cardiac ion channel activity, and properties that suggested the potential for clinical development for malaria. Careful examination of the bioavailability, pharmacokinetics, toxicology, and efficacy of this series
L Franqueza et al.
British journal of pharmacology, 125(5), 969-978 (1998-12-10)
1. The goal of this study was to analyse the effects of propafenone and its major metabolite, 5-hydroxy-propafenone, on a human cardiac K+ channel (hKv1.5) stably expressed in Ltk- cells and using the whole-cell configuration of the patch-clamp technique. 2.
David J Lowes et al.
Journal of medicinal chemistry, 54(21), 7477-7485 (2011-10-01)
Propafenone, a class Ic antiarrythmic drug, inhibits growth of cultured Plasmodium falciparum. While the drug's potency is significant, further development of propafenone as an antimalarial would require divorcing the antimalarial and cardiac activities as well as improving the pharmacokinetic profile
G Christé et al.
European journal of pharmacology, 373(2-3), 223-232 (1999-07-22)
Propafenone, a class I antiarrhythmic agent, inhibits several membrane currents (I(Na), I(Ca), I(K), Ito), however, its effects on ATP-sensitive potassium current (I(K)ATP) of cardiac cells have not been tested. We evaluated the blocking effects of 0.1 to 100 microM propafenone
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Global Trade Item Number

SKUGTIN
P4670-5G04061834375067

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