L135

L-741,626

Name: L-741,626
Brand: SIGMA
Price: 135.15 EUR

≥98% (HPLC)

Synonym(e):

(±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole

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10 MG

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₀H₂₁ClN₂O

CAS-Nummer:

81226-60-0

Molekulargewicht:

340.85

NACRES:

NA.77

PubChem Substance ID:

24278529

UNSPSC Code:

12352200

MDL number:

MFCD00953632

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥20 mg/mL, ethanol: 24 mg/mL, H₂O: insoluble

storage temp.

room temp

SMILES string

OC1(CCN(CC1)Cc2c[nH]c3ccccc23)c4ccc(Cl)cc4

InChI

1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2

InChI key

LLBLNMUONVVVPG-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815)

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Dieser Artikel	SML0369	SML1804	H1512
Sigma-Aldrich L135 L-741,626	Sigma-Aldrich SML0369 CID-2011756	Sigma-Aldrich SML1804 AM4113	Sigma-Aldrich H1512 Haloperidol
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay -
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. room temp	storage temp. room temp	storage temp. 2-8°C	storage temp. -
solubility DMSO: ≥20 mg/mL, H₂O: insoluble, ethanol: 24 mg/mL	solubility DMSO: 10 mg/mL (clear solution)	solubility DMSO: 2 mg/mL, clear (warmed)	solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL, 0.1 M HCl: 3 mg/mL, DMSO: soluble, H₂O: insoluble, ethanol: soluble
color white to beige	color white to beige	color white to brown	color white

Application

L-741,626 has been used as selective dopamine (D₂) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells.[1] It has also been used as a D₂ receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.[2]

Biochem/physiol Actions

L-741,626 is a selective dopamine (D₂) receptor antagonist.[3]

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Blockade of dopamine D(3) receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: similar actions of D(1) receptor agonists, but not of D(2) antagonists.

Florence Loiseau et al.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(1), 23-33 (2008-09-17)

Though D(3) receptor antagonists can enhance cognitive function, their sites of action remain unexplored. This issue was addressed employing a model of social recognition in rats, and the actions of D(3) antagonists were compared to D(1) agonists that likewise possess

Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626.

B J Bowery et al.

British journal of pharmacology, 119(7), 1491-1497 (1996-12-01)

1. The ability of PD 128907 to activate dopamine receptors in the ventral tegmental area, substantia nigra pars compacta, and striatum was investigated by use of in vitro electrophysiological recording and fast cyclic voltammetry. The affinity of a novel D2

D2 Dopamine receptor subtype mediates the inhibitory effect of dopamine on TRH-induced prolactin release from the bullfrog pituitary.

Masaki Nakano et al.

General and comparative endocrinology, 168(2), 287-292 (2010-06-18)

Dopamine receptors in mammals are known to consist of two D1-like receptors (D1 and D5) and three D2-like receptors (D2, D3 and D4). The aim of this study was to determine the dopamine receptor subtype that mediates the inhibitory action

PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion.

Alexander Gont et al.

Oncotarget, 8(5), 8559-8573 (2017-01-05)

A defining feature of the brain cancer glioblastoma is its highly invasive nature. When glioblastoma cells are isolated from patients using serum free conditions, they accurately recapitulate this invasive behaviour in animal models. The Rac subclass of Rho GTPases has

Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects.

Gregory T Collins et al.

The Journal of pharmacology and experimental therapeutics, 325(2), 691-697 (2008-02-29)

Food restriction enhances sensitivity to the reinforcing effects of a variety of drugs of abuse including opiates, nicotine, and psychostimulants. Food restriction has also been shown to alter a variety of behavioral and pharmacological responses to dopaminergic agonists, including an

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Global Trade Item Number

SKU	GTIN
L135-10MG	04061832091716
L135-50MG	04061832091723

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L-741,626