This product has not been tested for solubility in DMSO. However, product 612030 is a Nicotine solution prepared at 2 mg/mL in DMSO. In addition, external sources indicate that this material is soluble up to 30 mg/mL in DMSO. Other solvents include Methanol, Ethanol, Dimethylformamide, and Chloroform.
N3876
(−)-Nicotina
≥99% (GC), Prototype nicotinic acetylcholine receptor agonist, liquid
Sinónimos:
(−)-1-Metil-2-(3-piridil)pirrolidina, (S)-3-(1-Metil-2-pirrolidinil)piridina
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Fórmula empírica (notación de Hill):
C10H14N2
Número CAS:
Peso molecular:
162.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
200-193-3
MDL number:
Beilstein/REAXYS Number:
82109
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Servicio técnico
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Permítanos ayudarleNombre del producto
(−)-Nicotina, ≥99% (GC), liquid
Quality Level
assay
≥99% (GC)
form
liquid
optical activity
[α]20/D −169°(lit.)
color
yellow
refractive index
n20/D 1.5265 (lit.)
solubility
ethanol: 50 mg/mL
density
1.010 g/mL at 20 °C (lit.)
SMILES string
CN1CCC[C@H]1c2cccnc2
InChI
1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
InChI key
SNICXCGAKADSCV-JTQLQIEISA-N
Gene Information
human ... CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNB2(1141), CHRNB4(1143), CYP2A6(1548), KCNH1(3756)
mouse ... Chrna7(11441), Chrnb1(11443)
rat ... Chrna1(79557), Chrna2(170945), Chrna4(25590), Chrna7(25302), Chrnb2(54239), Chrnb4(25103)
General description
La nicotina es el alcaloide más abundante encontrado en las hojas de las especies del género Nicotiana. Es un agente tóxico importante.
Application
La (-)-nicotina se ha utilizado:
- para estimular los neutrófilos en ensayos de fluorescencia de ADN extracelular y en inmunotinción de neutrófilos
- para estudiar los efectos de la exposición crónica neonatal a la nicotina en la unión al receptor nicotínico de la acetilcolina (nAChR), la muerte celular y la morfología del hipocampo y el cerebelo
- en un estudio in vitro para evaluar el efecto de la exposición radicular a la nicotina o la cotinina en la morfología y densidad de los fibroblastos
Biochem/physiol Actions
Receptor prototipo agonista nicotínico de la acetilcolina; isómero que se encuentra en estado natural.
La nicotina se une a los receptores nicotínicos de acetilcolina y exhibe efectos a la vez neuroprotectores y neurotóxicos en el cerebro en desarrollo. Se asocia con el desarrollo de cáncer de pulmón y reduce la eficiencia de los quimioterápicos. Además, la nicotina tiene capacidad para deteriorar la defensa fagocítica del huésped y también aumenta la lesión asociada a las especies de oxígeno reactivo (ROS). También detiene la desactivación de la Akt/ proteincinasa B (PKB) y reduce la muerte espontánea de los neutrófilos. La nicotina se utiliza para el tratamiento de las enfermedades de Alzheimer y de Parkinson.
Preparation Note
Este producto debe ser disuelto en etanol puro de 200 grados.
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signalword
Danger
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
Clase de almacenamiento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
213.8 °F - closed cup
flash_point_c
101 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Contenido relacionado
Nicotine induces neutrophil extracellular traps
Hosseinzadeh A, et al.
Journal of Leukocyte Biology, 100(5), 1105-1112 (2016)
Root surface conditioning with nicotine or cotinine reduces viability and density of fibroblasts in vitro
Martinez AE, et al.
Clinical Oral Investigations, 9(3), 180-186 (2005)
Nicotine alkaloid levels, and nicotine to nornicotine conversion, in Australian Nicotiana species used as chewing tobacco
Moghbel N, et al.
Heliyon, 3(11), e00469-e00469 (2017)
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| N3876-25ML | 04061838256102 |
| N3876-5ML | 04061838256119 |
| N3876-100ML | 04061838256096 |
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Is that product soluble in DMSO?
1 answer-
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Is product N3876 (-)-Nicotine considered freebase nicotine or a nicotine salt dissolved in a carrier liquid
1 answer-
This product is nicotine free base and is provided in the form of a neat or pure liquid.
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Hi , How i want to measure the purity level of nicotine? Can refractive index or polarimeter use to measure level of impurity?
1 answer-
The measurement of purity in nicotine can be assessed using various analytical techniques. Refractive index and polarimetry are among the methods that can provide useful information. However, it's important to note that these techniques may not directly measure specific impurities but can be indicative of changes in the overall composition or characteristics of a substance. The purity of this product is determined by GC. Gas Chromatography (GC) is a widely used and effective method for assessing the purity of nicotine and detecting impurities. GC separates and analyzes components based on their volatility and interaction with a stationary phase.
Please access a Certificate of Analysis in the DOCUMENTATION section for reference:
https://www.sigmaaldrich.com/product/sigma/n3876#product-documentationHelpful?
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Hello, I would like to know the concentration of the nicotine in this liquid solution.
1 answer-
This product is a neat or pure liquid. Based on the density of 1.02 g/mL and the molecular weight of 162.2 g/mole, the calculated molar concentration is 6.3 M.
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How long is the nicotine stable if stored at room temperature? How long is it stable after being dssiolved and how should the solution be stored?
1 answer-
This compound is stored at room temperature, but is extremely sensitive to light, moisture, and oxygen. The product is a neat liquid and packaged in amber glass under argon to preserve stability. In the unopened container, the product is stable at least until the recommended retest date reported on the lot specific Certificate of Analysis. This date is typically 3 years from the quality release date. Factors such as light, humidity, and exposure to air will limit the shelf life after opening, It is recommended to prepare solutions fresh. The vial head space should be cleared with argon or nitrogen prior to closing. Increased darkening of the material is an indication of product degradation. Please see the link below to review a sample Certificate of Analysis:
https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/N3876-BULKBCCK8089.pdfHelpful?
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what % of ethanol should be used to be solublized?
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This product should be dissolved in 200-proof, pure ethanol.
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What is the molarity of Product N3876, (-)-Nicotine?
1 answer-
The molarity of (-)-Nicotine is 6.23 M based on a 100% pure compound with a density at 20 °C equal to 1.010 g/mL. If you multiply this density by 1000, you obtain g/L. If you divide g/L by the molecular weight of (-)-Nicotine which is 162.2 g/mole, you get moles per L which is molarity. [1.010 x 1000]/162.2 = 6.23 M.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the difference between Nicotine, Products N3876 and N0267?
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Prod. No. N3876 is the naturally occurring (-) isomer while Prod. No. N0267 is a mixture of the (+) and (-) isomers.
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How can Product N3876, (-)-Nicotine, be solublized?
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Product N3876, (-)-Nicotine, is soluble in ethanol. It is only miscible in water. We would recommend to solublized the product in ethanol to make a 1000x stock solution. This can then be diluted 1:1000 into aqueous buffer for use.
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