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Merck
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Documentos

2011

Millipore

Bilirubin

solid, bile pigment, Calbiochem®

Sinónimos:

Bilirubin

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About This Item

Fórmula empírica (notación de Hill):
C33H36N4O6
Número de CAS:
635-65-4
Peso molecular:
584.66
MDL number:
MFCD00005499
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Bilirubin, Principal pigment of bile and one of the major end products of hemoglobin decomposition.

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

red-brown

solubility

chloroform: 1 mg/mL
alkaline solution: soluble

shipped in

ambient

Storage temp.

10-30°C

InChI

1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-

Inchi Key

BPYKTIZUTYGOLE-IFADSCNNSA-N

General description

Bilirubin is an orange-yellow bile pigment and one of the major end products of hemoglobin decomposition. It contains conjugated double bonds and reactive hydrogen atoms. In adults, the upper limit of the normal range of bilirubin is >1mg/dL. Serum levels of bilirubin in healthy newborns are less than 15 mg/dl. This product corresponds to the unconjugated form.

Biochem/physiol Actions

Bilirubin is reported to cross the blood-brain barrier and exert significant antioxidant effects in the brain. This pigment aids in coloration in the various forms of jaundice. Bilirubin levels act as biomarkers in liver and blood disorders. Unconjugated form of bilirubin at lower levels serves as a physiological antioxidant. However, increased concentration of bilirubin is toxic and leads to neonatal hyperbilirubinemia in neonates.

Reconstitution

Unstable in basic solutions; reconstitute just prior to use.

Other Notes

Extinction coefficient (454 nm, CHCl3):59,100-62,300 M-1cm-1.
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary Target

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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What's in a name? Physiologic and pathologic jaundice: the conundrum of defining normal bilirubin levels in the newborn.
M Jeffrey Maisels
Pediatrics, 118(2), 805-807 (2006-08-03)
Elisabeth Lobner et al.
Frontiers in bioengineering and biotechnology, 8, 49-49 (2020-03-03)
The transmembrane protein CD19 is exclusively expressed on normal and malignant B cells and therefore constitutes the target of approved CAR-T cell-based cancer immunotherapies. Current efforts to assess CAR-T cell functionality in a quantitative fashion both in vitro and in
Zeng Hong et al.
ACS omega, 5(46), 29903-29912 (2020-12-01)
The reaction of magnesium or zinc amides with alkyl or benzyl halides is an attractive approach to make C-N bonds, especially for electron-poor organic halides. The magnesium-promoted preparation of hindered non-nucleophilic amine (N,N-diisopropylethylamine) from ethyl chloride and zinc diisopropylamide has
E Jiménez et al.
Environmental toxicology and pharmacology, 80, 103464-103464 (2020-08-05)
The identification of substances that prevent or minimize the detrimental effects of ionizing radiation is an essential undertaking. The aim of this paper was to evaluate and compare the radioprotective potential of chlorophyllin, protoporphyrin and bilirubin, with amifostine®, an US
James Chen et al.
Molecular cell, 78(2), 275-288 (2020-03-12)
Transcription initiation requires formation of the open promoter complex (RPo). To generate RPo, RNA polymerase (RNAP) unwinds the DNA duplex to form the transcription bubble and loads the DNA into the RNAP active site. RPo formation is a multi-step process
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