1029002

Amitriptyline hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Fórmula empírica (notación de Hill): C₂₀H₂₃N · HCl
• Número CAS: 549-18-8
• Peso molecular: 313.86
• NACRES: NA.24
• PubChem Substance ID: 329749005
• UNSPSC Code: 41116107
• MDL number: MFCD00012537

Propiedades

• grade: pharmaceutical primary standard
• agency: USP
• API family: amitriptyline
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• InChI key: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530), SLC6A4(6532)

Descripción

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amitriptyline hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Amitriptyline Hydrochloride Tablets
• Chlordiazepoxide and Amitriptyline Hydrochloride Tablets
• Cyclobenzaprine Hydrochloride Extended-Release Capsules
• Perphenazine and Amitriptyline Hydrochloride Tablets

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Información de seguridad

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• hcodes: H301,H319,H361fd,H410
• pcodes: P202 - P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338