This product has not been tested for use in cell culture. The solubility is tested at 50 mg/mL in a 95:5, v/v mixture of Chloroform and Methanol. The powder is insoluble in aqueous solutions such as cell culture medium. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/402/405/p7769pis.pdf
P7769
1,2-Diacyl-sn-glycero-3-phospho-L-serine
from bovine brain, ≥97% (TLC), amorphous powder, structural phospholipid
Sinónimos:
3-sn-Phosphatidyl-L-serine, L-α-Phosphatidyl-L-serine, PS, Phosphatidylserine
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
5 mg | Comprobar disponibilidad del carrito | $73.400 |
25 mg | Envío estimado HOYdesdePUDAHUEL | $195.000 |
100 mg | Comprobar disponibilidad del carrito | $633.000 |
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UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (TLC)
Form:
amorphous powder
Servicio técnico
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Permítanos ayudarleNombre del producto
1,2-Diacyl-sn-glycero-3-phospho-L-serine, ≥97% (TLC), from bovine brain, amorphous powder
biological source
bovine brain
Quality Segment
assay
≥97% (TLC)
form
amorphous powder
storage temp.
−20°C
Application
1,2-Diacyl-sn-glycero-3-phospho-L-serine has been used:
- as a lipid standard in time-of-flight secondary ion mass spectrometry (ToF-SIMS) spectral fingerprints
- as a reference standard in thin layer chromatography (TLC) for quantifying lipids from astrocyte-conditioned media (ACM) treated fibroblasts
- as a component of large unilamellar vesicles for annexin A2 aggregation studies
Biochem/physiol Actions
A slowly metabolized structural phospholipid found mainly in gray matter.
1,2-Diacyl-sn-glycero-3-phospho-L-serine or phosphatidylserine (PS) is a structurally diverse acidic phospholipid having fatty acid ester at the glycerol sn positions. Bovine brain cortex based PS is a potent brain nutrient. It favors neurotransmission and may improve memory in dementia. PS is also the major membrane phospholipid associated with the nuclear membrane, myelin, endoplasmic reticulum, Golgi and mitochondria. The synthesis of PS is catalyzed by phosphatidylserine synthase 1 from L-serine and CDP-diacylglycerol in the mitochondria-associated membrane (MAM) domains of the endoplasmic reticulum. PS is externalized during phagocytosis and is dysregulated in tumors making it a potential marker for therapeutic targeting.
Features and Benefits
This compound is featured on the Phospholipase D and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Solutions exposed to room temperature will decompose about 0.5% per day.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Hi I am going to purchase phsophatidylserine (P7769). What is the solvent for this? Is it better to use powder one or solution one for the cell assay?
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