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MSQC8

SigmaMAb Antibody Drug Conjugate (ADC) Mimic

Antibody Cysteine-Fluorophore Conjugate Standard

Sinónimos:

Antibody Drug Conjugate

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Tamaño de envaseSKUDisponibilidadPrecio
0.5 mg
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$816.000

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NACRES:
NA.32
UNSPSC Code:
12352204
Clone:
-
Species reactivity:
-
Application:
—
Citations:
1

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recombinant

expressed in CHO cells

Quality Level

200

antibody product type

primary antibodies

form

lyophilized powder

shipped in

wet ice

storage temp.

−20°C

General description

SigmaMab Antibody Drug Conjugate (ADC) Mimic, is a non-toxic drug mimic that is utilized as a standard for mass spectrometry and high performance liquid chromatography. The ADC Mimic conjugates SigmaMab (MSQC4), an IgG1 monoclonal antibody, to dansyl fluorophores via an LC-SMCC crosslinker. This dansyl-LC-SMCC attachment serves as the substitution for the toxic payload of a real ADC.

The ADC Mimic allows for safer and more consistent testing, making it the optimal product over real ADCs. It is also a more affordable product compared to real ADCs. With the help of this non-toxic product, LC-MS processes can be developed in a safer environment.

Application

Poster: Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

Poster: LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

Poster: LC-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC Mimic

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Sigma-Aldrich

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form

lyophilized powder

form

solid

form

-

form

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

recombinant

expressed in CHO cells

recombinant

expressed in CHO cells

recombinant

expressed in CHO cells

recombinant

expressed in CHO cells

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

antibody product type

primary antibodies

antibody product type

-

antibody product type

-

antibody product type

primary antibodies

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number
0000540144
0000529511
0000540144
0000529511
0000470442

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Protocolos

Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

Here we show how LC and MS methods may be optimized using a non-toxic surrogate of the ADC, an “ADC-mimic”, that behaves very similarly to the Cys-linked ADC Adcetris (Seattle Genetics).

LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

SigmaMab Antibody Drug Conjugate Mimic, is a non-toxic drug mimic utilized as a standard for mass spectrometry and high performance liquid chromatography.

Artículos

Analysis of mAb and ADC on Widepore Silica Monolith Column

Intact analysis of Universal Antibody Standard human and Antibody-Drug Conjugate (ADC) Mimic on silica monolithic HPLC columns under various conditions.

Contenido relacionado

Data Sheet - MSQC8

Instructions

Craig Jakes et al.
Analytical chemistry, 93(40), 13505-13512 (2021-09-30)
Monoclonal antibodies (mAbs) and related products undergo a wide range of modifications, many of which can often be directly associated to culture conditions during upstream processing. Ideally, such conditions should be monitored and fine-tuned based on real-time or close to

Número de artículo de comercio global

SKUGTIN
MSQC8-0.5MG04061833254820

Questions

1–2 of 2 Questions  

  1. Is the primary sequence of the antibody available?

    1 answer

    1. SigmaMAb Antibody Drug Conjugate (ADC) Mimic consists of the human universal monoclonal antibody standard (Catalog Number MSQC4, an IgG1 monoclonal antibody) conjugated to dansyl fluorophores via an LC-SMCC crosslinker.

      The sequence of MSQC4 can be found in the user guide. Sequence Information:

      1. SigmaMAb Heavy Chain:
      EVQLVESGGGLVQPGGSLRLSCVASGFTLNNYD MHWVRQGIGKGLEWVSKIGTAGDRYYAGSVKGR FTISRENAKDSLYLQMNSLRVGDAAVYYCARGAG RWAPLGAFDIWGQGTMVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVD VSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNS TYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPI EKTISKAKGQPREPQVYTLPPSRDELTKNQVSLT CLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDS DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPG

      2. SigmaMAb Light Chain:
      QSALTQPRSVSGSPGQSVTISCTGTSSDIGGYNF VSWYQQHPGKAPKLMIYDATKRPSGVPDRFSGS KSGNTASLTISGLQAEDEADYYCCSYAGDYTPGV VFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANK ATLVCLISDFYPGAVTVAWKADSSPVKAGVETTT PSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVT HEGSTVEKTVAPTECS

      Helpful?

  2. Does MSQC8 (SigmaMAb Antibody Drug Conjugate (ADC) Mimic) has light chain lambda or gamma?

    1 answer

    1. This antibody has both lambda light chains and gamma heavy chains.

      Helpful?

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