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M0252

Methylglyoxal solution

~40% in H2O

Sinónimos:

Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde

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Fórmula lineal:
CH3COCHO
Número CAS:
78-98-8
Peso molecular:
72.06
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
24896540
MDL number:
MFCD00006960
Beilstein/REAXYS Number:
906750
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form

liquid

Quality Segment

200

concentration

~40% (enzymatic), ~40% in H2O

density

1.17 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

[H]C(=O)C(C)=O

InChI

1S/C3H4O2/c1-3(5)2-4/h2H,1H3

InChI key

AIJULSRZWUXGPQ-UHFFFAOYSA-N

General description

Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.

Application

Methylglyoxal solution has been used:
  • to assess glyoxalase 1 (GLO1) enzymatic activity[1]
  • as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro
  • to regulate anxiety like behavior in mice
  • to induce peritoneal fibrosis in rats
  • to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts
  • for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway

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Este artículo
W29690267028739685
Methylglyoxal solution ~40% in H2O

Sigma-Aldrich

M0252

Methylglyoxal solution

Pyruvaldehyde solution 40 wt. % in H2O

Sigma-Aldrich

W296902

Pyruvaldehyde solution

Methylglyoxal solution technical, ~40% in H2O

Sigma-Aldrich

67028

Methylglyoxal solution

Methylglyoxal-13C3 solution 20 wt. % in H2O, 99 atom % 13C

Sigma-Aldrich

739685

Methylglyoxal-13C3 solution

Quality Level

200

Quality Level

300, 400

Quality Level

200

Quality Level

-

form

liquid

form

-

form

-

form

solution

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

density

1.17 g/mL at 25 °C (lit.)

density

1.178 g/mL at 25 °C

density

1.19 g/mL at 20 °C

density

-

concentration

~40% (enzymatic)

concentration

40 wt. % in H2O

concentration

~40% in H2O

concentration

20 wt. % in H2O

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Danger

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Clase de almacenamiento

10 - Combustible liquids

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Certificados de análisis (COA)

Lot/Batch Number
WXBF5825V
WXBF4459V
WXBF4922V
WXBF3145V
BCCJ9027

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Artículos

Quantification of Methylglyoxal in Manuka Honey - A Simple HPTLC Based Approach

High-Performance Thin-Layer chromatography (HPTLC) quantification of methylglyoxal (MGO) in complex and matrix rich manuka honey offering quick sample preparation, high-matrix tolerance, and high-throughput.

Número de artículo de comercio global

SKUGTIN
M0252-1L04061837841026
M0252-500ML04061837841040
M0252-250ML04061837841033
M0252-25ML04061833992784
M0252-100ML04061833992777

Questions

1–8 of 8 Questions  

  1. What Solvent should I use first to make intermediate stock eg 5mL of 10mM from 6.49M? final working solution i will use for Cell cytotoxicity test.

    1 answer

    1. Researchers indicate this product has been diluted in PBS for cytotoxicity assays. Please refer to the citation below and consider reviewing peer reviewed literature for application specific information.

      He, T., Zhou, H., Li, C., Chen, Y., Chen, X., Li, C., … Meng, Q. H. (2016). Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression. Cancer Biology & Therapy, 17(9), 955–965. https://doi.org/10.1080/15384047.2016.1210736

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. 40%ということですが、25ml中10g程度のMGOが含まれるという理解でよろしいでしょうか。

    1 answer

    1. The 40% approximation is mass/mass. In 25 grams of product, there will be 10 grams of methylglyoxal. The density of this preparation is 1.17 g/mL at 25 °C.

      Helpful?

  5. What are the mass and concentration of 25ML methylglyoxal solution?

    1 answer

    1. As per the webpage of M0252: https://www.sigmaaldrich.com/product/sigma/m0252
      The density is 1.17 g/mL at 25 °C (lit.). So the mass of 25 mL = 1.17 x 25 =29.25 g.
      The concentration = Density x w/w% x 1000 / Molecular Weight = 1.17 x 40% x 1000 / 72.06 = 6.49 mol/L.

      Helpful?

  6. Hi I am using this chemical for my research, could you please tell me the molarity of this solution? 

    1 answer

    1. The molarity of the Methylglyoxal solution is approximately 6.49 M. This value may be calculated as follows:
      Molarity = Density x w/w% x 1000 / Mw = 1.17 x 40% x 1000 / 72.06 = 6.49 mol/L

      Helpful?

  7. How to dilute methylglyoxal? What is the stock concentration?

    1 answer

    1. The stock concentration will range from 4.89 M to 8.11 M, depending on the percent methylglyoxal - the specification ranges from 30 % to 50 %. The molecular weight of methylglyoxal is 72.06 g/mol.

      Using the catalog density of 1.17 g/mL at 25 °C, the molarity would calculate to 6.49 molar for a 40 % solution (1,170 g/L × 0.40 = 468 g/L; 468 g/L divided by 72.06 = 6.49 M).

      The actual % concentration is reported on the lot-specific Certificate of Analysis.

      See the link below to access a specific lot or to review a sample Certificate:
      https://www.sigmaaldrich.com/US/en/product/sigma/m0252#product-documentation

      The solution is aqueous and may be further diluted in more water. If diluting with an organic solvent is preferred, ether or alcohols (i.e. ethanol, methanol) are also miscible with water.

      Helpful?

  8. Is the listed density, 1.17 g/ml, for the entire solution i.e. the Methylglyoxal in water or just the Methylglyoxal compound? 

    1 answer

    1. The density is 1.17 g/mL for the prepared solution.

      Helpful?

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