L6004

Lincomycin hydrochloride

≥90% (TLC)

• Sinónimos: Epilincomycin, Lincomycin HCL, Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride
• Fórmula empírica (notación de Hill): C₁₈H₃₄N₂O₆S · HCl
• Número CAS: 859-18-7
• Peso molecular: 443.00
• UNSPSC Code: 51284507
• NACRES: NA.85
• PubChem Substance ID: 329817633
• EC Number: 212-726-7
• Beilstein/REAXYS Number: 4171650
• MDL number: MFCD00083647

Propiedades

• Quality Segment: 200
• assay: ≥90% (TLC)
• potency: 800-900 units per mg
• color: white to faint yellow
• solubility: H₂O: soluble 50 mg/mL
• antibiotic activity spectrum: Gram-positive bacteria
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O
• InChI: 1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1
• InChI key: POUMFISTNHIPTI-BOMBIWCESA-N

Descripción

General description

Chemical structure: macrolide

Application

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance, and protein and surfactant binding [1][2] It is produced by Streptomyces lincolnensis var. lincolnensis.

Biochem/physiol Actions

Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.†

Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.

Preparation Note

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves