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Documentos clave

I4269

Sigma-Aldrich

IL-4 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinónimos:

IL-4, Interleukin-4 human, hIL-4

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About This Item

Número MDL:
MFCD00151705
Código UNSPSC:
12352202
NACRES:
NA.77

Nombre del producto

Interleukin-4 human, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

origen biológico

human

Nivel de calidad

200

recombinante

expressed in E. coli

Ensayo

≥98% (SDS-PAGE)

Formulario

lyophilized powder

potencia

≤0.400 ng/mL EC50

calidad

endotoxin tested

mol peso

14.9 kDa (containing 129 amino acid residues)

envase

pkg of 5 and 50 μg

técnicas

cell culture | mammalian: suitable

impurezas

≤1.000 EU/μg

color

white

Nº de acceso UniProt

P05112

temp. de almacenamiento

−20°C

Información sobre el gen

human ... IL4(3565)
mouse ... IL4(3565)

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Descripción general

Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including differentiation of naive T cells into the TH2 phenotype, promoting B cell proliferation, antibody isotype switching, and expression of other TH2 cytokines including IL-5 and IL-9.1,2 IL-4 plays a critical role in the development of allergic inflammation and asthma.3

IL-4 binds to two distinct receptors; the type I receptor, a heterodimer consisting of the IL-4Rα chain and the common gamma chain, γc, and the type II receptor, a heterodimer of IL-4Rα and IL-13Rα1.4

Naturally occurring IL-4 has a molecular mass of 12-20 kDa. Recombinant human IL-4 is a 14.9 kDa protein containing 129 amino acid residues. Human and mouse IL-4 share a 50% amino acid sequence homology, but their biological actions are species-specific.5

Aplicación

Lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and βFGF-induced angiogenesis.

Forma física

Lyophilized from a sterile filtered solution.

Nota de análisis

The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000397155
0000397156
0000397155
0000397156
0000331972

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Sigma-Aldrich

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IL-13 Variant human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sigma-Aldrich

SRP3076

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Interleukin-4 from rat recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)

Sigma-Aldrich

I3650

Interleukin-4 from rat

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Polymorphic effector proteins determine the susceptibility of Toxoplasma gondii strains to IFN-γ-mediated clearance mechanisms deployed by murine host cells. However, less is known about the influence of these polymorphic effector proteins on IFN-γ-independent clearance mechanisms. Here, we show that deletion
T Yokota et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(16), 5894-5898 (1986-08-01)
A cDNA sequence coding for a human interleukin has been isolated from a concanavalin A-activated human T-cell cDNA library based on homology with a mouse interleukin cDNA that expresses B-cell stimulatory factor 1 (BSF-1) activity and T-cell- and mast-cell-stimulating activities.
Zhu Wang et al.
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Diabetic nephropathy (DN) is a common complication of diabetes mellitus which can result in renal failure and severely affect public health. Several studies have revealed the important role of podocyte injury in DN progression. Although, the involvement of exosomes derived
Shweta Arora et al.
Cells, 10(8) (2021-08-28)
Macrophage polarization and infiltration to the tumor microenvironment (TME) is a critical determining factor for tumor progression. Macrophages are polarized into two states-M1 (pro-inflammatory, anti-tumorigenic and stimulated by LPS or IFN-γ) and M2 (anti-inflammatory pro-tumorigenic and stimulated by IL-4) phenotypes.
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Apolipoprotein (a)/lipoprotein(a) (Lp(a)), a major carrier of oxidized phospholipids, and α7-nicotinic acetylcholine receptor (α7-nAChR) may play an important role in the development of coronary artery spasm (CAS). In CAS, the association between Lp(a) and the α7-nAChR-modulated inflammatory macrophage polarization and
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