This understanding is correct, however, the stabilizer content is approximately 70%. The lot-specific Certificate of Analysis will provide the exact stabilizer content, which can then be used to calculate the amount of β-Estradiol 3-Sulfate.
https://www.sigmaaldrich.com/product/sigma/e9505#product-documentation
E9505
β-Estradiol 3-sulfate sodium salt
≥93%
Sinónimos:
1,3,5(10)-Estratriene-3,17β-diol 3-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-sulfate
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25 MG
$80.100
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25 MG
$80.100
About This Item
Fórmula lineal:
C18H23O5SNa
Número de CAS:
Peso molecular:
374.43
Número MDL:
Código UNSPSC:
51111800
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
esterilidad
non-sterile
Nivel de calidad
Ensayo
≥93%
Formulario
powder
contiene
~70% N-methyl-D-glucamine as stabilizer
solubilidad
methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
Condiciones de envío
ambient
temp. de almacenamiento
room temp
cadena SMILES
[Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24
InChI
1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,17+,18+;;/m1../s1
Clave InChI
PYPVMTJYMKHIST-LBARCDFESA-N
Descripción general
β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.[1]
Aplicación
β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.[2]
Acciones bioquímicas o fisiológicas
β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity.[3] β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy.[4] 17-β-Estradiol is the most active estrogen generated in our body.[5] During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.[6]
Envase
Package size based on steroid content
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Vimal Kumar et al.
Chemosphere, 82(8), 1124-1128 (2010-12-28)
The occurrence of free and conjugated estrogens was examined in a survey of eleven sewage treatment plants (STPs) and their discharge water in the United Kingdom using grab sampling. The STPs included trickling filter with and without tertiary treatment, and
Li-Quan Wang et al.
The Journal of steroid biochemistry and molecular biology, 96(5), 367-374 (2005-07-14)
Using recombinant sulfotransferases (SULTs) expressed in E. coli, beta-estradiol (E2) sulfonation was examined to determine which SULT enzyme is responsible for producing E2-17-sulfate (E2-17-S). SULTs 1A1*1, 1A1*2, 1A3, 1E1 and 2A1 all sulfated E2 to varying extents. No activity was
Y M Qian et al.
The Journal of biological chemistry, 276(9), 6404-6411 (2000-12-05)
Multidrug resistance protein 1 (MRP1) is an ATP-binding cassette (ABC) transporter that transports a range of hydrophobic xenobiotics, as well as relatively hydrophilic organic anion conjugates. The protein is present at high levels in testicular Leydig and Sertoli cells. Studies
Jared Winikor et al.
Reproductive sciences (Thousand Oaks, Calif.), 18(7), 654-665 (2011-01-29)
The most abundant form of estrogen circulating in fetal plasma is sulfo-conjugated estrogen; for example, estradiol-3-sulfate (E(2)SO(4)) is more highly abundant than estradiol (E(2)). The present study investigated the ontogeny of the deconjugating (steroid sulfatase [STS]) and conjugating (estrogen sulfotransferase
Antonio Nieto et al.
Journal of chromatography. A, 1213(2), 224-230 (2008-11-04)
In this study we present a pressurized liquid extraction/liquid chromatography-tandem mass spectrometry (PLE/LC-MS-MS) method to determine a group of estrogens and conjugated estrogens in sewage sludge. Parameters that affect the extraction step such as extraction solvent, temperature, pressure, static extraction
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The description of the product says that it contains 70 % N-methyl-D-glucamine as a stabilizer. Does this mean that 1.0 mg of the powder contains 0.3 mg of β-Estradiol 3-sulfate and that I need to weigh in 3.33 mg of the powder to get 1 mg of substance?
1 answer-
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