C4780

Coenzima A sodium salt hydrate

BioReagent, suitable for cell culture

• Sinónimos: CoA Na₂
• Fórmula empírica (notación de Hill): C₂₁H₃₆N₇O₁₆P₃S · xNa⁺ · yH₂O
• Número CAS: 55672-92-9
• Peso molecular: 767.53 (anhydrous free acid basis)
• MDL number: MFCD00079020
• UNSPSC Code: 12352205
• PubChem Substance ID: 24892723
• EC Number: 259-747-8
• NACRES: NA.75

Propiedades

• biological source: yeast
• Quality Level: 200
• description: cofactor for acyl transfer
• product line: BioReagent
• assay: ≥85% (HPLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: [Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• InChI: 1S/C21H36N7O16P3S.Na/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H
• InChI key: SYTRWOCXZXQBPW-CLVRNSBASA-M

Descripción

Application

Coenzyme A sodium salt hydrate has been used:

• in the branch chain aminotransferase enzymatic assay and protein determination
• in the assay for halogenation of pyrrolyl-S-Bmp1 (an acyl carrier protein (ACP)-thioesterase (TE) di-domain protein) by Bmp2
• as an extracellular coenzyme A (CoA) in in vitro and in vivo experiments to study alternative routes by which cells and organisms can obtain CoA

Biochem/physiol Actions

Coenzyme A (CoA) is a ubiquitous cofactor that plays an important role in many metabolic pathways, mainly as acyl-CoA. It is essential for the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. CoA facilitates acyl group transfers, especially in fatty acid and lipid metabolism reactions. It is associated with neurodegeneration, autophagy, protein acetylation, and signal transduction.

Analysis Note

Enzymatically assayed using phosphotransacetylase. Approx. 95% CoA-SH

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)