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C1145

Cholesterol–PEG 600

Sinónimos:

Cholesterol, water soluble from sheep, Cholesteryl-polyethylene glycol 600 sebacate, Polyethylene glycol 600 mono(cholesteryl) ether sebacate, Polyoxyethyl-cholesteryl sebacate

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Número CAS:
69068-97-9
UNSPSC Code:
41141804
eCl@ss:
39023139
NACRES:
NA.77
MDL number:
MFCD00151772
Form:
solid
Quality level:
200
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form

solid

Quality Level

200

extent of labeling

≥20% cholesterol

color

light yellow

solubility

H2O: 60 mg/mL

shipped in

dry ice

storage temp.

−20°C

General description

Cholesterol is one of the important constituent of all membranes. It is made up of a hydrophobic, planar, a polar hydroxyl group, fused-ring nucleus and a short hydrocarbon tail.

Application

Cholesterol-PEG 600 has been used to evaluate its ability to induce apoptosis in vascular smooth muscle cells. It has also been used to restore cholesterol following depletion by methyl β-cyclodextrin.

Biochem/physiol Actions

Cholesterol acts as an antecedent of steroid hormones. It plays a key role in fetal growth and in brain development.

Physical form

semisolid to solid

Preparation Note

Prepared by method of Proksch, G.J., and Bonderman, D.P., Clin. Chem., 24, 1924 (1978).

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Este artículo
880001O880001M700041P
Cholesterol–PEG 600

Sigma-Aldrich

C1145

Cholesterol–PEG 600

Chol-PEG600 Avanti Research™ - A Croda Brand 880001O

Avanti

880001O

Chol-PEG600

Chol-PEG600 Avanti Research™ - A Croda Brand 880001M, methylene chloride solution

Avanti

880001M

Chol-PEG600

cholesterol-d7 Avanti Research™ - A Croda Brand

Avanti

700041P

cholesterol-d7

form

solid

form

liquid

form

methylene chloride solution

form

powder

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

H2O: 60 mg/mL

solubility

-

solubility

-

solubility

-

color

light yellow

color

-

color

-

color

-

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000553050
0000553051
0000535758
0000535754
0000515419

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Artículos

Discover Bioactive Small Molecules for Lipid Signaling Research

Discover Bioactive Small Molecules for Lipid Signaling Research

Linda Shaw et al.
Cardiovascular research, 69(4), 825-835 (2006-02-09)
A close association of caveolae and sarcoplasmic reticulum (SR) has been suggested to be important for contractile activation of smooth muscle. Here, we investigate the presence of such arrangements in pressurised resistance arteries and examine the influence of two agents
M Absi et al.
British journal of pharmacology, 151(3), 332-340 (2007-04-24)
The small and intermediate conductance, Ca2+-sensitive K+ channels (SK(Ca) and IK(Ca), respectively) which are pivotal in the EDHF pathway may be differentially activated. The importance of caveolae in the functioning of IK(Ca) and SK(Ca) channels was investigated. The effect of
The Lipids of Biological Membranes
The Membranes of Cells null
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Número de artículo de comercio global

SKUGTIN
C1145-5G04061833075937
C1145-250MG04061833075913
C1145-1G04061826690093
C1145-500MG04061833461297

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. こんにちは こちらの製品に含まれているPEG600の割合を可能な範囲で教えていただくことは可能でしょうか。 お手数をおかけいたしますが、よろしくお願いいたします。

    1 answer

    1. There is not a formal molecular weight provided for this product.

      Cholesterol molecular weight = 386.65 g/mole.
      Sebacic Acid molecular weight = 202.25 g/mole
      PEG molecular weight = ~600 g/mole.

      Based on one cholesterol, one sebacic acid "linker" and one PEG (molecular weight 600) per molecule of C1145, one can calculate an approximate molecular weight of 1188 g/mole.

      The approximate amount of PEG based upon this weight is 600/1150 or ~52%.

      Helpful?

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