Unforunately we do not have information on the cross-reactivity of the antibody B3648-.5ml with the cynomolgus. Additionally, no in-house epitope mapping has been conducted on this antibody. However, Robert G. Hamilton and Sherie L. Morrison, in their 1993 article in the Journal of Immunological Methods, have performed some further characterization. According to the article, "The anti-human IgG4 MAbs (HP6023, HP6025) bound to a similar epitope on the carboxyl terminus of CH2 or the CH3 of human IgG4." For more details, please refer to the article: "Journal of Immunological Methods Volume 158, Issue 1, 14, Pages 107-122."
B3648
Anti-Human IgG4−Biotin antibody, Mouse monoclonal
clone HP-6025, purified from hybridoma cell culture
Sinónimos:
Monoclonal Anti-Human IgG4
Iniciar sesión para ver los precios por organización y contrato.
Seleccione un Tamaño
Cambiar Vistas
| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 0.2 mL | Comprobar disponibilidad del carrito | $198.000 | |
| 0.5 mL | Comprobar disponibilidad del carrito | $392.000 |
Acerca de este artículo
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
biotin conjugate
Clone:
HP-6025, monoclonal
Application:
ELISA (d)
Citations:
35
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarlebiological source
mouse
Quality Level
conjugate
biotin conjugate
antibody form
purified immunoglobulin
antibody product type
secondary antibodies
clone
HP-6025, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
direct ELISA: 1:60,000
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Application
Anti-Human IgG4−Biotin antibody, Mouse monoclonal has been used in immunohistochemistry and immunostaining.
Monoclonal Anti-Human IgG4-Biotin antibody produced in mouse may be used in ELISA at a working dilution of 1:15,000. It was used for detection of serum IgG4 produced in response to malaria parasite infection by ELISA.
The IUIS/WHO2 study singled out this monoclonal antibody as one of the most widely applicable IgG4 specific monoclonal antibodies. Monoclonal Anti-Human IgG4 may be used for the identification of the IgG4 subclass by various immunoassays including: ELISA, Imprint Immunofixation (IIF), Immunofluorometric Assay (IFMA), Hemagglutination (HA), Hemagglutination Inhibition (HAI), Particle Counting Immunoassay (PACIA), and detection of cytoplasmic IgG.
Biochem/physiol Actions
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections. The coupling of biotin to monoclonal Anti-Human IgG4 antibody allows for the binding of various labels such as avidin or streptavidin.
IgG4 is the least abundant immunoglobulin present in the human serum. IgG4 is implicated in a unique process called fab-arm exchange (FAE) and limits the formation of immune complex. It has anti-inflammatory properties. IgG4 functions as a therapeutic antibody. It provides protection against allergy, prevents mast cell degranulation and has a harmful role in malignant melanoma. IgG4 may be associated with autoimmune diseases such as, autoimmune pancreatitis (AIP) type 1 and 2, Mikulicz syndrome, Kuttner′s tumor, Riedel′s thyroiditis and tubulointerstitial nephritis.
Monoclonal Anti-Human IgG4 is specific for the IgG4 subclass and nonreactive with IgG1, IgG2 and IgG3 in an ELISA.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
Este artículo | |||
|---|---|---|---|
| biological source mouse | biological source mouse | biological source mouse | biological source mouse |
| species reactivity human | species reactivity human | species reactivity rabbit, sheep, horse (IgG), goat, human | species reactivity human |
| technique(s) direct ELISA: 1:60,000 | technique(s) direct ELISA: 1:30,000 | technique(s) direct ELISA: 1:80,000 | technique(s) direct ELISA: 1:40,000 |
| antibody form purified immunoglobulin | antibody form purified from hybridoma cell culture | antibody form purified immunoglobulin | antibody form purified from hybridoma cell culture |
| conjugate biotin conjugate | conjugate biotin conjugate | conjugate biotin conjugate | conjugate biotin conjugate |
| isotype IgG1 | isotype IgG1 | isotype IgG2a | isotype IgG1 |
Still not finding the right product?
Pruebe nuestra Herramienta de selección de productos para limitar sus opciones
Clase de almacenamiento
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Intranasal air sampling in homes: relationships among reservoir allergen concentrations and asthma severity
Gore RB, et al.
The Journal of Allergy and Clinical Immunology, 117(3), 649-655 (2006)
IgG4-related autoimmune diseases: Polymorphous presentation complicates diagnosis and treatment
Kleger A, et al.
Deutsches Arzteblatt International, 112(8), 128-128 (2015)
Hayder A Giha et al.
Malaria journal, 8, 306-306 (2009-12-24)
Plasmodium falciparum malaria is a complex disease in which genetic and environmental factors influence susceptibility. IgG isotypes are in part genetically controlled, and GM/KM allotypes are believed to be involved in this control. In this study, 216 individuals from Daraweesh
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| B3648-.5ML | 04061837514845 |
| B3648-.2ML | 04061833428306 |
-
Does the antibody B3648-.5ml cross-react with the cynomolgus monkey?
1 answer-
Helpful?
-