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A9501

Adenosine 3′,5′-cyclic monophosphate

Name: Adenosine 3&#8242;,5&#8242;-cyclic monophosphate
Brand: SIGMA
Price: 246000 CLP
Availability: InStock

≥98.5% (HPLC), powder, PKA activator

Sinónimos:

3′,5′-Cyclic AMP, Adenosine 3′,5′-cyclophosphate, cAMP

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Tamaño de envase	Disponibilidad	Precio
1 g	Disponible para enviar HOYdesdePUDAHUEL	$246.000
5 g	Comprobar disponibilidad del carrito	$933.000
25 g	Comprobar disponibilidad del carrito	$2.880.000

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₀H₁₂N₅O₆P

Número CAS:

60-92-4

Peso molecular:

329.21

NACRES:

NA.77

PubChem Substance ID:

24278245

eCl@ss:

32160414

UNSPSC Code:

41106305

EC Number:

200-492-9

MDL number:

MFCD00005845

Beilstein/REAXYS Number:

52645

Assay:

≥98.5% (HPLC)

Form:

powder

$246.000

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Propiedades

Nombre del producto

Adenosine 3′,5′-cyclic monophosphate, ≥98.5% (HPLC), powder

Quality Segment

200

assay

≥98.5% (HPLC)

form

powder

color

white

mp

260 °C (dec.) (lit.)

solubility

H₂O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.)

storage temp.

−20°C

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O

InChI

1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

InChI key

IVOMOUWHDPKRLL-KQYNXXCUSA-N

Gene Information

human ... OPRK1(4986)

Descripción

Application

Adenosine 3′,5′-cyclic monophosphate has been used:

as cell culture medium supplement in embryonic spinal neurons
as a component of ringer solution for perfusion studies[1]
to induce neuroendocrine differentiation in human lung cancer cell lines

Biochem/physiol Actions

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). The cAMP/PKA signaling pathway inhibits cell proliferation, induces differentiation and leads to apoptosis.

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Features and Benefits

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Este artículo	A6885	G6129	SML1229
Sigma-Aldrich A9501 Adenosine 3′,5′-cyclic monophosphate	Sigma-Aldrich A6885 Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate	Sigma-Aldrich G6129 Guanosine 3′,5′-cyclic monophosphate sodium salt	Sigma-Aldrich SML1229 2′,3′-cGAMP sodium salt
assay ≥98.5% (HPLC)	assay ≥98.0% (HPLC)	assay ≥99% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.)	solubility H₂O: 10 mg/mL	solubility H₂O: 50 mg/mL	solubility -
color white	color white	color white	color white to beige