This product is recombinant enzyme produced in e. coli. The original species information is not available.
49641
Alcohol Dehydrogenase, recombinant
≥500 U/mL
Sinónimos:
Alcohol:NADP+ oxidoreductase
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Número CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
≥500 U/mL
Recombinant:
expressed in E. coli
recombinant
expressed in E. coli
form
liquid
specific activity
≥500 U/mL
technique(s)
cell based assay: suitable
color
light brownish-yellow to brown-green
suitability
suitable for molecular biology
application(s)
life science and biopharma
storage temp.
−20°C
General description
Research area: Neuroscience
Alcohol dehydrogenase has a homodimeric structure with a co-enzyme binding domain at the C-terminal and an N-terminal catalytic domain. The active site is located at the interdomain cleft.[1] Binding of NAD+ in the active site [2] causes conformational changes that create the binding site for the alcohol substrate.[3]
Alcohol dehydrogenase has a homodimeric structure with a co-enzyme binding domain at the C-terminal and an N-terminal catalytic domain. The active site is located at the interdomain cleft.[1] Binding of NAD+ in the active site [2] causes conformational changes that create the binding site for the alcohol substrate.[3]
Application
Alcohol dehydrogenase (ADH) has been used for the reversal of deficient 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay reduction in the disrupted schizophrenia 1 (DISC1-FL) and DB7 cell lysate.
Biochem/physiol Actions
Alcohol dehydrogenase catalyzes the oxidative conversion of alcohol into aldehyde.[4] The metabolism of ethanol catalyzed by alcohol dehydrogenase (ADH) results in the generation of reactive oxygen species (ROS) and nitric oxide (NO) leading to oxidative damage to mitochondria and cellular proteins and is further associated with the onset of neuroinflammation and neurological disorders.
Other Notes
1 U corresponds to the amount of enzyme which reduces 1 μmol acetone per minute at pH 7.0 and 30°C (NADPH as cofactor)
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Este artículo | |||
|---|---|---|---|
| technique(s) cell based assay: suitable | technique(s) - | technique(s) - | technique(s) - |
| specific activity ≥500 U/mL | specific activity ≥90 U/mg | specific activity - | specific activity ≥60 units/mg protein |
| application(s) life science and biopharma | application(s) - | application(s) - | application(s) - |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant - | recombinant - |
| form liquid | form powder | form powder | form lyophilized powder |
| suitability suitable for molecular biology | suitability - | suitability - | suitability - |
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Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2
Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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From what organism is this alcohol dehydrogenase from
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