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M1629

Sigma-Aldrich

Medroxyprogesteron-17-Acetat

≥97% (HPLC)

Synonym(e):

17α-Acetoxy-6α-methylprogesteron, 17α-Hydroxy-6α-methyl-4-pregnen-3,20-dion-17-acetat, 6α-Methyl-17α-acetoxyprogesteron, 6α-Methyl-17α-hydroxyprogesteron-acetat

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About This Item

Empirische Formel (Hill-System):
C24H34O4
CAS-Nummer:
71-58-9
Molekulargewicht:
386.52
Beilstein:
2066112
EG-Nummer:
200-757-9
MDL-Nummer:
MFCD00010483
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24896674
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Sterilität

non-sterile

Assay

≥97% (HPLC)

Form

powder

mp (Schmelzpunkt)

206-207 °C (lit.)

Löslichkeit

chloroform: 350 mg/mL, clear, colorless

Versandbedingung

ambient

Lagertemp.

room temp

SMILES String

[H][C@@]12C[C@H](C)C3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(OC(C)=O)C(C)=O

InChI

1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1

InChIKey

PSGAAPLEWMOORI-PEINSRQWSA-N

Angaben zum Gen

human ... AR(367) , ESR1(2099) , ESRRA(2101) , NR3C1(2908) , NR3C2(4306) , PGR(5241)
rat ... Ar(24208)

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Biochem./physiol. Wirkung

Medroxyprogesterone 17-acetate (MPA) is a synthetic progestin used as a contraceptive, in hormone replacement therapy and for the treatment of endometriosis. It is a more potent progestin that the nonacetylated form.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Health hazard
GHS08

Signalwort

Warning

H-Sätze

H351,H413

Gefahreneinstufungen

Aquatic Chronic 4 - Carc. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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PloS one, 10(10), e0137855-e0137855 (2015-10-06)
Use of long-acting progestin only contraceptives (LAPCs) offers a discrete and highly effective family planning method. Abnormal uterine bleeding (AUB) is the major side effect of, and cause for, discontinuation of LAPCs. The endometria of LAPC-treated women display abnormally enlarged
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Journal of assisted reproduction and genetics, 28(1), 7-14 (2010-09-16)
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S Saoncella et al.
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